Cortical excitability and interhemispheric inhibition after subcortical pediatric stroke: plastic organization and effects of rTMS.

Arterial ischemic stroke (AIS) causes disability in children but plastic developmental neurophysiology is unstudied. Imbalance of interhemispheric inhibition (IHI) in adult subcortical stroke is a therapeutic target. We hypothesized that IHI imbalance occurs in childhood AIS and is modifiable by rTMS. Eligible SickKids Children's Stroke Program patients included children >7years with subcortical AIS (>2years previous) and functional hand impairment. TMS with electromyography over first dorsal interosseous measured baseline motor cortex (M1) rest and 1mV thresholds and stimulus-response curves (100-150%). Paired-pulse TMS studied bidirectional short (SIHI) and long (LIHI) interval IHI. Children were matched for age/weakness and randomized to contralesional inhibitory rTMS or sham (8days) with measures repeated. Ten children (mean 13.9 years) had variable weakness (4 mild/2 moderate/4 severe). Stroke M1 motor thresholds were elevated (75±25% versus 55±14%, p=0.05) and decreased with age. Baseline measures suggested excessive LIHI from non-stroke to stroke side (-46±17% versus -28±23%, p=0.08). Following inhibitory rTMS, increases in stroke side maximal MEP amplitudes were suggested and LIHI from stroke to non-stroke side appeared to increase (-20% to -40%). Procedures were well tolerated. TMS measurement of developmental plastic organization and rTMS interventions are feasible in childhood stroke and IHI imbalance may occur. Improved understanding of developmental plasticity after childhood stroke will facilitate better rehabilitational therapy.

Kirton A ，Deveber G ，Gunraj C ，Chen R ... -  《-》

Contralesional repetitive transcranial magnetic stimulation for chronic hemiparesis in subcortical paediatric stroke: a randomised trial.

Kirton A ，Chen R ，Friefeld S ，Gunraj C ，Pontigon AM ，Deveber G ... -  《LANCET NEUROLOGY》

Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke.

Nowak DA ，Grefkes C ，Dafotakis M ，Eickhoff S ，Küst J ，Karbe H ，Fink GR ... -  《-》

Effect of low-frequency repetitive transcranial magnetic stimulation on interhemispheric inhibition.

Pal PK ，Hanajima R ，Gunraj CA ，Li JY ，Wagle-Shukla A ，Morgante F ，Chen R ... -  《JOURNAL OF NEUROPHYSIOLOGY》

Relationship between interhemispheric inhibition and motor cortex excitability in subacute stroke patients.

Bütefisch CM ，Wessling M ，Netz J ，Seitz RJ ，Hömberg V ... -  《NEUROREHABILITATION AND NEURAL REPAIR》