Synthesis and in vitro evaluation of 18F labeled tyrosine derivatives as potential positron emission tomography (PET) imaging agents.

Three new 18F labeled fluoroalkyl tyrosine derivatives, O-(2-[18F]fluoroethyl)-alpha-methyltyrosine (FEMT, [18F]2), O-(2-[18F]fluoroethyl)-2-L-azatyrosine (FEAT, [18F]3), O-(2-[18F]fluoroethyl)-L-tyrosineamide (FETA, [18F]4) have been synthesized and radiofluorinated with 5-34% decay-corrected yield. In vitro studies were carried out in U-138 MG human glioblastoma. Cellular uptake of new tracers was compared to clinically utilized imaging agent O-(2-[18F]fluoroethyl)-L-tyrosine (FET, [18F]1). The uptake of tracers followed the order of FET ([18F]1) > FEAT([18F]3) > FEMT ([18F]2) approximately FETA ([18F]4).

Wang L ，Qu W ，Lieberman B ，Ploessl K ，Kung HF ... -  《-》

Investigation of transport mechanism and uptake kinetics of O-(2-[18F]fluoroethyl)-L-tyrosine in vitro and in vivo.

Heiss P ，Mayer S ，Herz M ，Wester HJ ，Schwaiger M ，Senekowitsch-Schmidtke R ... -  《-》

A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling.

VanBrocklin HF ，Blagoev M ，Hoepping A ，O'Neil JP ，Klose M ，Schubiger PA ，Ametamey S ... -  《-》

No carrier added synthesis of O-(2'-[18F]fluoroethyl)-L-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base.

Krasikova RN ，Kuznetsova OF ，Fedorova OS ，Maleev VI ，Saveleva TF ，Belokon YN ... -  《-》

Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.

Toyokuni T ，Kumar JS ，Walsh JC ，Shapiro A ，Talley JJ ，Phelps ME ，Herschman HR ，Barrio JR ，Satyamurthy N ... -  《-》