Highly oxygenated guaianolides from Artemisia dubia.

Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A-H, 1-8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1-8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA-MB-435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA-MB-435 cells.

Huang ZS ，Pei YH ，Liu CM ，Lin S ，Tang J ，Huang DS ，Song TF ，Lu LH ，Gao YP ，Zhang WD ... -  《-》

Dimeric guaianolides and sesquiterpenoids from Artemisia anomala.

Wen J ，Shi H ，Xu Z ，Chang H ，Jia C ，Zan K ，Jiang Y ，Tu P ... -  《-》

New guaianolides from Artemisia anomala.

Hu ZH ，Zhang P ，Huang DB ，Wu JZ ... -  《-》

Dimeric guaianolides from Artemisia absinthium.

Five dimeric guaianolides, absinthins A-E, and seven known dimeric guaianolides were isolated from Artemisia absinthium. Their structures were elucidated based on 1D- and 2D-NMR experiments, including (1)H NMR, (13)C NMR, DEPT, (1)H-(1)H COSY, HSQC, HMBC, and NOESY, and through HRESIMS data analysis. The absolute configuration of the known compound, anabsinthin, was determined by X-ray crystallographic analysis. The isolated compounds were tested to assess their inhibitory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 cells; absinthin C and isoanabsinthin exhibited significant inhibitory effects with IC50 values of 1.52 and 1.98μM, respectively.

Turak A ，Shi SP ，Jiang Y ，Tu PF ... -  《-》

Highly oxygenated sesquiterpenes in Artemisia alba Turra.

Ten new sesquiterpene alcohols of which seven germacranes, a eudesmane, a guaiane and an oplopane were isolated from the aerial parts of Artemisia alba Turra. Their structures and relative stereochemistry were elucidated by spectral methods ((1)H and (13)C NMR, COSY, HSQC, HMBC, NOESY, and MS). In addition, the known 7-hydroxycadin-4-en-3-one, centaureidin and axillarin were found for the first time in the studied species.

Todorova M ，Trendafilova A ，Danova K ，Simmons L ，Wolfram E ，Meier B ，Riedl R ，Evstatieva L ... -  《-》