No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer.

The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.

Freiberger T ，Ravcuková B ，Grodecká L ，Kurecová B ，Jarkovský J ，Bartonková D ，Thon V ，Litzman J ... -  《-》

Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin.

Dechavanne C ，Dechavanne S ，Sadissou I ，Lokossou AG ，Alvarado F ，Dambrun M ，Moutairou K ，Courtin D ，Nuel G ，Garcia A ，Migot-Nabias F ，King CL ... -  《-》

Maternal-Foetal Diabetes Modifies Neonatal Fc Receptor Expression on Human Leucocytes.

This study investigated the expression of the neonatal Fc receptor (FcRn) in maternal blood, cord blood and placental cells and determined IgG levels in maternal blood and cord blood from diabetic mothers. Peripheral blood, cord blood and placenta samples were collected from 26 mothers with normoglycaemia (non-diabetic, ND group) and 52 with hyperglycaemia (26 with mild gestational hyperglycaemia, MGH group, and 26 with type 2 diabetes mellitus, DM-2 group). Cells expressing CD19(+) and FcRn were identified by flow cytometry. Total IgG and its subclasses were quantified by ELISA. Maternal blood from DM-2 and cord blood from MGH exhibited a higher proportion of CD19(+) expression by B cells. DM-2 showed a lower proportion of CD19(+) cells in placenta. FcRn expression increased in cells from cord blood and placenta from MGH. Maternal blood, cord blood and placenta cells from DM-2 showed lower FcRn expression. Blood IgG levels were lower in DM-2, and cord blood IgG levels were higher in MGH. The highest levels of IgG4 were detected in the blood of hyperglycaemic mothers. The highest IgG3 and IgG4 levels in cord blood were detected in MGH, and the lowest IgG2 and IgG3 levels in DM-2. Maternal hyperglycaemia compromised placental transfer of IgG1, IgG3 and IgG4. The results suggest that regardless of hyperglycaemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.

de Souza EG ，Hara CC ，Fagundes DL ，de Queiroz AA ，Morceli G ，Calderon IM ，França EL ，Honorio-França AC ... -  《-》

Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport.

Leach JL ，Sedmak DD ，Osborne JM ，Rahill B ，Lairmore MD ，Anderson CL ... -  《JOURNAL OF IMMUNOLOGY》

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies.

Borghi S ，Bournazos S ，Thulin NK ，Li C ，Gajewski A ，Sherwood RW ，Zhang S ，Harris E ，Jagannathan P ，Wang LX ，Ravetch JV ，Wang TT ... -  《-》