Effect of peripheral arterial disease on in-hospital outcomes after primary percutaneous coronary intervention for acute myocardial infarction.

The presence of peripheral arterial disease (PAD) in patients with stable coronary artery disease is associated with an increased long-term risk of death, myocardial infarction, and stroke. However, the effect of PAD on short-term outcomes in patients with acute myocardial infarction is less well understood. A total of 9,015 consecutive patients with acute myocardial infarction from the New York State Coronary Angioplasty Reporting System database, all of whom had undergone primary percutaneous coronary intervention in 1998 and 1999, were analyzed. The diagnosis of PAD was determined by a history of aortoiliac, femoral-popliteal, or carotid disease. A logistic regression model was used to determine the relation between PAD and in-hospital death and major adverse cardiovascular events, which included a composite of death, recurrent myocardial infarction, stroke, acute vessel occlusion, stent thrombosis, emergency coronary artery bypass surgery, and vascular injury. PAD had been diagnosed in 529 (5.9%) of the 9,015 patients. Patients with PAD had greater rates of diabetes mellitus, hypertension, and chronic kidney disease and were significantly more likely to develop heart failure, cardiogenic shock, and hemodynamic instability. The incidence of major adverse cardiovascular events was significantly greater in patients with PAD than in patients without PAD (20.4% vs 7.0%, p <0.001). Similarly, the in-hospital mortality rate was significantly greater among the patients with PAD (13% vs 3.8%, p <0.001). After adjusting for the baseline and procedural characteristics, PAD remained an independent predictor of in-hospital mortality (odds ratio 2.2, 95% confidence interval 1.7 to 3.0, p <0.001). In conclusion, PAD was independently associated with a doubling of the in-hospital mortality risk among patients undergoing primary percutaneous coronary intervention for acute myocardial infarction.

Jeremias A ，Gruberg L ，Patel J ，Connors G ，Brown DL ... -  《-》

Vascular disease burden and in-hospital outcomes among patients undergoing percutaneous coronary intervention in New York State.

Berger JS ，Petersen JL ，Brown DL 《-》

Usefulness of the presence of peripheral vascular disease in predicting mortality in acute myocardial infarction patients treated with primary angioplasty (from the Primary Angioplasty in Myocardial Infarction Database).

Guerrero M ，Harjai K ，Stone GW ，Brodie B ，Cox D ，Boura J ，Grines L ，O'Neill W ，Grines C ... -  《AMERICAN JOURNAL OF CARDIOLOGY》

Optimal timing of coronary artery bypass after acute myocardial infarction: a review of California discharge data.

Weiss ES ，Chang DD ，Joyce DL ，Nwakanma LU ，Yuh DD ... -  《-》

The impact of advanced chronic kidney disease on in-hospital mortality following percutaneous coronary intervention for acute myocardial infarction.

The impact of advanced chronic kidney disease (CKD) on the outcomes of patients undergoing percutaneous coronary intervention (PCI) in the acute phase of myocardial infarction is poorly understood. We assessed the impact of CKD (stages 3-5) on the in-hospital outcomes of patients undergoing PCI for acute myocardial infarction (AMI) in a statewide registry. This study evaluated all patients who underwent PCI in New York State between 1997 and 1999. Of the 9,015 patients, 94 (1%) had at least stage 3 CKD (serum creatinine for AMI > 2.5 mg/dL) and were not on dialysis. Patients with advanced CKD were compared with those without advanced CKD using univariate and multivariate methods. The primary outcome of interest was in-hospital mortality. Patients with advanced CKD had a higher incidence of diabetes, hypertension, and peripheral vascular disease. Patients with advanced CKD presented more commonly with cardiogenic shock or heart failure. The unadjusted in-hospital mortality was 23.4% for patients with advanced CKD compared with 4.2% for patients without advanced CKD (P < 0.001). After adjusting for the increased comorbidity and high risk clinical features, advanced CKD remained an independent predictor of in-hospital mortality (odds ratio 2.4, 95% Confidence Interval, 1.002-5.804, P = 0.049). Patients with AMI and advanced CKD who undergo PCI have more comorbidities and significantly worse in-hospital outcomes than patients without advanced CKD. Even after adjusting for these comorbidities, advanced CKD remains an independent predictor of increased in-hospital mortality.

Vasu S ，Gruberg L ，Brown DL 《-》