Prognosis of atrial fibrillation in patients with symptomatic peripheral arterial disease: data from the REduction of Atherothrombosis for Continued Health (REACH) Registry.

Atrial fibrillation (AF) is a significant risk factor for cardiovascular (CV) mortality. This study aims to evaluate the prognostic implication of AF in patients with peripheral arterial disease (PAD). The International Reduction of Atherothrombosis for Continued Health (REACH) Registry included 23,542 outpatients in Europe with established coronary artery disease, cerebrovascular disease (CVD), PAD and/or > or =3 risk factors. Of these, 3753 patients had symptomatic PAD. CV risk factors were determined at baseline. Study end point was a combination of cardiac death, non-fatal myocardial infarction (MI) and stroke (CV events) during 2 years of follow-up. Cox regression analysis adjusted for age, gender and other risk factors (i.e., congestive heart failure, coronary artery re-vascularisation, coronary artery bypass grafting (CABG), MI, hypertension, stroke, current smoking and diabetes) was used. Of 3753 PAD patients, 392 (10%) were known to have AF. Patients with AF were older and had a higher prevalence of CVD, diabetes and hypertension. Long-term CV mortality occurred in 5.6% of patients with AF and in 1.6% of those without AF (p<0.001). Multivariable analyses showed that AF was an independent predictor of late CV events (hazard ratio (HR): 1.5; 95% confidence interval (CI): 1.09-2.0). AF is common in European patients with symptomatic PAD and is independently associated with a worse 2-year CV outcome.

Winkel TA ，Hoeks SE ，Schouten O ，Zeymer U ，Limbourg T ，Baumgartner I ，Bhatt DL ，Steg PG ，Goto S ，Röther J ，Cacoub PP ，Verhagen HJ ，Bax JJ ，Poldermans D ... -  《-》

Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis.

Goto S ，Bhatt DL ，Röther J ，Alberts M ，Hill MD ，Ikeda Y ，Uchiyama S ，D'Agostino R ，Ohman EM ，Liau CS ，Hirsch AT ，Mas JL ，Wilson PW ，Corbalán R ，Aichner F ，Steg PG ，REACH Registry Investigators ... -  《-》

New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft.

El-Chami MF ，Kilgo P ，Thourani V ，Lattouf OM ，Delurgio DB ，Guyton RA ，Leon AR ，Puskas JD ... -  《-》

Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry.

Uchiyama S ，Goto S ，Matsumoto M ，Nagai R ，Origasa H ，Yamazaki T ，Shigematsu H ，Shimada K ，Yamada N ，Bhatt DL ，Steg PG ，Ikeda Y ，REduction of Atherothrombosis for Continued Health Registry Investigators ... -  《-》

Prognostic impact of types of atrial fibrillation in acute coronary syndromes.

Lau DH ，Huynh LT ，Chew DP ，Astley CM ，Soman A ，Sanders P ... -  《-》