Cardiovascular event rates in diabetic and nondiabetic individuals with and without established atherothrombosis (from the REduction of Atherothrombosis for Continued Health [REACH] Registry).

The objective of this study was to determine cardiovascular event rates in diabetic patients and nondiabetic subjects from the REACH Registry with established coronary artery disease, cerebrovascular disease, peripheral arterial disease, or multiple risk factors for atherothrombosis. REACH is an international, prospective, and contemporaneous cohort of patients with > or = 3 atherothrombotic risk factors only or established atherothrombotic disease, of which 30,043 have diabetes. The main outcomes after 1-year follow-up were cardiovascular death, myocardial infarction, stroke, major adverse cardiovascular events (MACEs; cardiovascular death, myocardial infarction, or stroke), and MACEs/hospitalization. The MACE rate at 1 year was positively related to the number of atherothrombotic anatomic sites in diabetic patients and nondiabetic subjects, and the rate was higher in those with (3.8%) than without (3.0%, p <0.001) diabetes. Diabetic patients with risk factors only had a lower MACE rate than nondiabetic subjects or diabetic patients with established atherothrombotic disease (2.2% vs 4.0% or 6.0%, respectively, p <0.001 for the 2 comparisons). These differences persisted after adjusting for gender and age. In conclusion, diabetic patients in the REACH Registry have an increased risk of cardiovascular events compared to nondiabetic subjects related to the number of atherothrombotic sites. Although increasing risk, diabetes may not be truly equivalent to previous atherothrombotic events on new cardiovascular event rates.

Krempf M ，Parhofer KG ，Steg PG ，Bhatt DL ，Ohman EM ，Röther J ，Goto S ，Pasquet B ，Wilson PW ，Reach Registry Investigators ... -  《-》

Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry.

Uchiyama S ，Goto S ，Matsumoto M ，Nagai R ，Origasa H ，Yamazaki T ，Shigematsu H ，Shimada K ，Yamada N ，Bhatt DL ，Steg PG ，Ikeda Y ，REduction of Atherothrombosis for Continued Health Registry Investigators ... -  《-》

Cardiovascular risk profile and outcome of patients with abdominal aortic aneurysm in out-patients with atherothrombosis: data from the Reduction of Atherothrombosis for Continued Health (REACH) Registry.

Baumgartner I ，Hirsch AT ，Abola MT ，Cacoub PP ，Poldermans D ，Steg PG ，Creager MA ，Bhatt DL ，REACH Registry investigators ... -  《-》

Cardiovascular ischemic event rates in outpatients with symptomatic atherothrombosis or risk factors in the united states: insights from the REACH Registry.

Eagle KA ，Hirsch AT ，Califf RM ，Alberts MJ ，Steg PG ，Cannon CP ，Brennan DM ，Bhatt DL ，REACH Registry Investigators ... -  《-》

Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis.

Goto S ，Bhatt DL ，Röther J ，Alberts M ，Hill MD ，Ikeda Y ，Uchiyama S ，D'Agostino R ，Ohman EM ，Liau CS ，Hirsch AT ，Mas JL ，Wilson PW ，Corbalán R ，Aichner F ，Steg PG ，REACH Registry Investigators ... -  《-》