Different cross-reactivity of human and rodent sera to Tula virus and Puumala virus.

Tula virus (TULV) and Puumala virus (PUUV) are hantaviruses carried by the bank vole (Myodes glareolus) and European common vole (Microtus arvalis), respectively. PUUV is a causative agent of hemorrhagic fever with renal syndrome (HFRS), while TULV is thought to be apathogenic to humans. The N-terminal regions of the N proteins from TULV and PUUV were expressed and applied as enzyme-linked immunosorbent assay (ELISA) antigens. Colonized Japanese grass voles (Microtus montebelli) and BALB/c mice were used for experimental inoculation of the vole-borne hantaviruses TULV and PUUV. Voles and mice showed significant antibody production toward both viruses, but these antisera showed little cross-reactivity between TULV and PUUV in the immunofluorescence antibody assay and ELISA. In contrast, sera from patients with HFRS caused by PUUV exhibited high cross-reactivity against the TULV antigen, and sera from a natural rodent reservoir showed moderate cross-reactivity against the heterologous antigen, indicating that the antigenic cross-reactivity between TULV and PUUV differs in sera from rodents and humans.

Tegshduuren E ，Yoshimatsu K ，Taruishi M ，Endo R ，Shimizu K ，Koma T ，Yasuda SP ，Kariwa H ，Arikawa J ，Ishihara C ... -  《-》

[Variants of the immunoreactivity and infectious process in bank vole (Myodes glareolus) experimentally infected with the hantavirus Puumala (PUUV)].

Apekina NS ，Bernshteĭn AD ，Demina VT ，Gavrilovskaia IN ... -  《-》

Cross-protection against challenge with Puumala virus after immunization with nucleocapsid proteins from different hantaviruses.

de Carvalho Nicacio C ，Gonzalez Della Valle M ，Padula P ，Björling E ，Plyusnin A ，Lundkvist A ... -  《-》

Puumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages.

Bourquain D ，Bodenstein C ，Schürer S ，Schaade L ... -  《Viruses-Basel》

Serological survey of Seewis virus antibodies in patients suspected for hantavirus infection in Finland; a cross-reaction between Puumala virus antiserum with Seewis virus N protein?

Ling J ，Vaheri A ，Hepojoki S ，Levanov L ，Jääskeläinen A ，Henttonen H ，Vapalahti O ，Sironen T ，Hepojoki J ... -  《-》