HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children.

Few data are available on the prevalence of celiac disease (CD)-predisposing, HLA-related genes in Arab populations. To investigate the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with CD and healthy controls. We tested 31 Libyan children with CD (22 females and 9 males, median age 9.2 years) and 156 Libyan controls (81 females and 75 males, median age 10.9). HLA genes were determined on a drop of dried blood by the DQ-CD Typing Plus kit (DiaGene, Palermo, Italy). The HLA-DQ pattern of the 31 CD children was: hetero DQ2 (n=15), DQ2 with homo beta2 (10), DQ8 and beta2 positive (3), DQ8 (2), and hetero beta2 (1). The HLA-DQ pattern of the 156 controls was: hetero DQ2 (n=36), hetero beta2 (30), DQ2-DQ8 negative (23), DQ8 (19), alpha5 (14), DQ2 with homo beta (12), homo beta2 (10), DQ8 and beta2 positive (7), and DQ2/DQ8 (5). HLA-DQ2 and -DQ8 in CD patients are as common in Libya as in Italy, but the frequency of "high-risk" genotypes is higher in Libyan than Italian patients. The prevalence of HLA-DQ2 and -DQ8 genes in the Libyan general population is higher than in Italy, indicating a strong genetic predisposition to CD.

Alarida K ，Harown J ，Di Pierro MR ，Drago S ，Catassi C ... -  《-》

Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both.

Dezsofi A ，Szebeni B ，Hermann CS ，Kapitány A ，Veres G ，Sipka S ，Körner A ，Madácsy L ，Korponay-Szabó I ，Rajczy K ，Arató A ... -  《-》

HLA-DQ types of celiac disease in Libyan children with type 1 diabetes mellitus.

Ghawil M ，Miotti V ，Tonutti E ，Tenore A ，Hadeed I ，Sindici C ，Visentini D ，Morgham A ，Abusrewil S ... -  《-》

HLA-DQ and risk gradient for celiac disease.

Megiorni F ，Mora B ，Bonamico M ，Barbato M ，Nenna R ，Maiella G ，Lulli P ，Mazzilli MC ... -  《-》

Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles.

Pietzak MM ，Schofield TC ，McGinniss MJ ，Nakamura RM ... -  《-》