Maternal bipolar disorder increased low birthweight and preterm births: a nationwide population-based study.

To investigate pregnancy outcomes, including low birthweight, preterm births, and small-for-gestational-age (SGA) among women with bipolar disorder, schizophrenia compared with women with no history of mental illness using nationwide population-based data. This study linked the Taiwan National Health Insurance Research Dataset with the national birth certificate registry. A total of 528,398 singleton births between 2001 and 2003 were included; 337 were diagnosed with bipolar disorder. Multivariate logistic regression analyses were carried out to examine the relationship between maternal bipolar disorder, schizophrenia and the odds of low birthweight, preterm births, and SGA, after adjusting for characteristics of infant, mother and father. It shows that pregnant women with bipolar disorder were more likely to have LBW infants (9.8% vs. 5.7%), preterm births (14.2% vs. 6.9%) and SGA (22.3% vs. 15.7%) than pregnant women with no history of mental illness. The adjusted odds of low birthweight for women with bipolar disorder was 1.66 times (95% CI, 1.16-2.38) that of women with no history of mental illness. In terms of preterm births and SGA, the adjusted odds ratios were 2.08 (95% CI, 1.53-2.83) and 1.47 (95% CI, 1.14-1.91) respectively, for women with bipolar disorder, compared to their counterparts with no history of mental illness. We conclude that women with bipolar disorder had increased risk of low birthweight, preterm births, and SGA than women without a history of mental illness. More active monitoring and early intervention to counter potential adverse pregnancy outcomes for pregnant women with bipolar disorder should be initiated.

Lee HC ，Lin HC 《-》

Prenatal care and adverse pregnancy outcomes among women with schizophrenia: a nationwide population-based study in Taiwan.

To compare the number of prenatal care visits for women with and without schizophrenia and to explore the relationship between the level of prenatal care and adverse pregnancy outcomes (low birth weight [LBW], preterm gestation, and small-for-gestational-age [SGA] babies). We identified a total of 607 women who gave birth from 2001 to 2003, who had been diagnosed with schizophrenia (ICD-9-CM criteria) in the 2 years preceding the index delivery, together with 1,821 matched women as a comparison cohort. Multivariate logistic regression and Poisson regression analyses were performed for estimation. Results show women with schizophrenia had a significantly lower mean number of prenatal care visits (7.92 vs 8.72, P <. 001). Multivariate logistic regression shows that, after adjusting for characteristics of mother and infant, women with schizophrenia were 1.77 (95% CI, 1.46-2.15; P <. 001) times more likely than women without schizophrenia to receive inadequate prenatal care. The results also show that after adjusting for other factors, schizophrenic women who received inadequate prenatal care were 2.47 (95% CI, 1.27-4.77; P = .007), 1.84 (95% CI, 1.02-3.37; P = .036), and 1.77 (95% CI, 1.15-2.73; P = .010) times more likely to have preterm births, LBW babies, and SGA babies, compared to schizophrenic women who received adequate care. We conclude that women with schizophrenia were more likely to receive inadequate prenatal care than women without this disorder. Schizophrenic women who received inadequate prenatal care had a higher risk of adverse pregnancy outcomes than schizophrenic women who received adequate care.

Lin HC ，Chen YH ，Lee HC 《-》

Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: a nationwide population-based study.

Lin HC ，Chen SF ，Lin HC ，Chen YH ... -  《-》

Increased risk of low birthweight and small for gestational age infants among women with tuberculosis.

Lin HC ，Lin HC ，Chen SF 《-》

Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study.

Chen YH ，Lin HC ，Chen SF ，Lin HC ... -  《-》