1H-MRSI of prostate cancer: the relationship between metabolite ratio and tumor proliferation.

To investigate whether 1H-MRSI can be used to predict the proliferative activity of prostate cancer. Thirty-eight patients with prostate cancer (PCa) and thirty-three patients with benign prostate hyperplasia (BPH) were included in this study. Patients were examined in supine position using a 1.5T superconducting magnetic scanner equipped with a pelvic phased-array multi-coil and CSI-3D-PROSTATE sequence. Commercial software was used to acquire and process MR spectroscopic imaging data. Mean (Cho+Cr)/Cit ratios of PCa, BPH, and peripheral zone (PZ) were calculated. Cellularity of PCa was recorded based on hematoxylin and eosin staining. PCNA was detected using immunohistochemical techniques. The mean (Cho+Cr)/Cit ratio of the peripheral zone (0.38+/-0.09) was lower than that of BPH (0.51+/-0.19) (P<0.05). The average value of (Cho+Cr)/Cit ratio of prostate cancer was 3.98+/-0.12. The (Cho+Cr)/Cit ratio of prostate cancer was higher than that of the peripheral zone and BPH (P<0.05). The cellularity and PCNA LI of prostate cancer were 12.90+/-4.07% and 72.1+/-19.01%, respectively. The (Cho+Cr)/Cit ratio of prostate cancer positively correlated with tumor cellularity (r=0.582, P=0.027) and PCNA LI (r=0.495, P=0.022). The (Cho+Cr)/Cit ratio of PCa can reveal the differences in proliferative activity between PCa and BPH. MRSIs are therefore able to predict the proliferative rate of variously differentiated prostate cancers.

Wang XZ ，Wang B ，Gao ZQ ，Liu JG ，Liu ZQ ，Niu QL ，Sun ZK ，Yuan YX ... -  《-》

Diffusion-weighted imaging of prostate cancer: correlation between apparent diffusion coefficient values and tumor proliferation.

Wang XZ ，Wang B ，Gao ZQ ，Liu JG ，Liu ZQ ，Niu QL ，Sun ZK ，Yuan YX ... -  《JOURNAL OF MAGNETIC RESONANCE IMAGING》

Combined use of diffusion-weighted MRI and 1H MR spectroscopy to increase accuracy in prostate cancer detection.

Reinsberg SA ，Payne GS ，Riches SF ，Ashley S ，Brewster JM ，Morgan VA ，deSouza NM ... -  《-》

Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines.

Shukla-Dave A ，Hricak H ，Moskowitz C ，Ishill N ，Akin O ，Kuroiwa K ，Spector J ，Kumar M ，Reuter VE ，Koutcher JA ，Zakian KL ... -  《RADIOLOGY》

Detection of prostate cancer with magnetic resonance imaging: optimization of T1-weighted, T2-weighted, dynamic-enhanced T1-weighted, diffusion-weighted imaging apparent diffusion coefficient mapping sequences and MR spectroscopy, correlated with biopsy a

Aydin H ，Kizilgöz V ，Tatar IG ，Damar C ，Ugan AR ，Paker I ，Hekimoğlu B ... -  《-》