Inhaled carbenoxolone prevents allergic airway inflammation and airway hyperreactivity in a mouse model of asthma.

Asthma is a chronic respiratory disease, which needs a safer medication preferably in inhalation form. In view of this, we have evaluated the effect of inhaled carbenoxolone (CBX), a herbal-derived compound, on asthma in a mouse model. Mice were sensitized and challenged with ovalbumin (OVA) to develop certain characteristic features of asthma such as airway hyperreactivity (AHR), airway eosinophilia, lung inflammation and mucus hypersecretion. To evaluate the effect of CBX on the above asthmatic features, CBX (2.5, 5 and 10 mg/ml, 3 ml) or vehicle (water) was given by inhalation. AHR was determined using whole-body plethysmography. Infiltration of eosinophils was estimated by microscopy. Lung inflammation and mucus hypersecretion were assessed using hematoxylin and eosin, and periodic acid-Schiff staining, respectively. Th-2 cytokines, IL-4 and IL-5 were measured in bronchoalveolar lavage (BAL) fluid and IgE in sera. To identify the possible mode of CBX action, we measured corticosterone levels in the BAL fluid and 5-lipoxygenase (5-LO) expression in the lungs. CBX (5 mg/ml) inhalation markedly alleviated AHR (p = 0.0032) and reduced lung inflammation and mucus hypersecretion. Also, it prevented the increase in IL-4 (p = 0.0192), IL-5 (p = 0.0116) and eosinophils (p < 0.0005) in the BAL fluid, and OVA-specific IgE levels (p = 0.00061) in sera. 5-LO expression was also markedly reduced. However, corticosterone levels were not affected. Inhaled CBX alleviates the asthmatic features in mice and could be a potent nebulized therapy in clinical asthma.

Ram A ，Singh SK ，Singh VP ，Kumar S ，Ghosh B ... -  《-》

Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.

Ram A ，Mabalirajan U ，Singh SK ，Singh VP ，Ghosh B ... -  《INTERNATIONAL IMMUNOPHARMACOLOGY》

4-1 BB stimulation inhibits allergen-specific immunoglobulin E production and airway hyper-reactivity but partially suppresses bronchial eosinophilic inflammation in a mouse asthma model.

Cho YS ，Kwon B ，Lee TH ，Kim TB ，Moon KA ，La S ，Lee J ，Lee SD ，Oh YM ，Moon HB ... -  《CLINICAL AND EXPERIMENTAL ALLERGY》

Glycyrrhizin alleviates experimental allergic asthma in mice.

Ram A ，Mabalirajan U ，Das M ，Bhattacharya I ，Dinda AK ，Gangal SV ，Ghosh B ... -  《INTERNATIONAL IMMUNOPHARMACOLOGY》

L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma.

Fiscus LC ，Van Herpen J ，Steeber DA ，Tedder TF ，Tang ML ... -  《JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY》