Role of long-term lamivudine treatment of hepatitis B virus recurrence after liver transplantation.

In this study, the long-term (>3 years) efficacy of combination therapy for hepatitis B virus (HBV) recurrence and the associated factors were investigated. One hundred and sixty-five consecutive HBsAg-positive patients (92 with liver cirrhosis, 73 with hepatocellular carcinoma; HCC) who underwent liver transplantation were assessed with a median follow-up time of 40 months. One hundred and twenty-one patients (121/165, 73.3%) were treated with lamivudine before transplantation for a mean of 8.4 months (range 0.1-72 months). The post-transplantation treatment protocol consisted of a high dose intravenous hepatitis B immunoglobulin (HBIg) followed by a low dose intramuscular HBIg and lamivudine combination therapy. Seven (4.2%, 7/165) recipients experienced HBV recurrence at a median time of 19 months (range 5-36 months) following transplantation. Six of seven cases of HBV recurrence were treated with lamivudine before transplantation for a median period of 15 months (range 0.6-30 months). Eighteen (24.6%, 18/73) patients had HCC recurrences after transplantation. Of the four patients with both HCC and HBV recurrence, three experienced HBV recurrence after recurrence of HCC. The clinical factor associated with HBV recurrence in the total cohort (n = 165) was the duration of antiviral treatment (over 6 months) before transplantation (P = 0.004). In the HCC group, HCC recurrence after transplantation (P = 0.002), tumor burden before transplantation (P = 0.005), and postoperative adjuvant chemotherapy (P = 0.002), were additional factors for HBV recurrence. Combination therapy of HBIg and antiviral drugs was effective over 3 years regardless of the pretransplantation viral load. However, the possible recurrence of HBV needs to be monitored cautiously in patients treated with long-term (over 6 months) lamivudine.

Woo HY ，Choi JY ，Jang JW ，You CR ，Bae SH ，Yoon SK ，Yang JM ，Choi SW ，Han NI ，Kim DG ... -  《-》

[Prevention and treatment of hepatitis B virus reinfection after liver transplantation].

Liu J ，Wu GC ，Zhang ZT ，Wu P ，Zhang D ，Sun MC ，Gao DC ，Wang Y ，Jia JD ，Wang BE ... -  《-》

Recurrence of hepatocellular carcinoma and hepatitis B reinfection in hepatitis B surface antigen-positive patients after liver transplantation.

Saab S ，Yeganeh M ，Nguyen K ，Durazo F ，Han S ，Yersiz H ，Farmer DG ，Goldstein LI ，Tong MJ ，Busuttil RW ... -  《-》

Lamivudine prophylaxis of liver allograft HBV reinfection in HBV related cirrhotic patients after liver transplantation.

Lu SC ，Yan LN ，Li B ，Wen TF ，Zhao JC ，Cheng NS ，Liu C ，Liu J ，Wang XB ，Li XD ，Qin S ，Zhao LS ，Lei BJ ，Zhang XH ... -  《Hepatobiliary & Pancreatic Diseases International》

Low-dose intramuscular hepatitis B immune globulin and lamivudine for long-term prophylaxis of hepatitis B recurrence after liver transplantation.

Ferretti G ，Merli M ，Ginanni Corradini S ，Callejon V ，Tanzilli P ，Masini A ，Ferretti S ，Iappelli M ，Rossi M ，Rivanera D ，Lilli D ，Mancini C ，Attili A ，Berloco P ... -  《TRANSPLANTATION PROCEEDINGS》