Osteopontin as a molecular prognostic marker for melanoma.

Osteopontin has been suggested as a marker of disease progression in patients with melanoma because of its overexpression in recent microarray analyses. However, its prognostic role in melanoma has not been fully defined. Osteopontin expression status was examined using immunohistochemical analysis of a tissue microarray that contained primary cutaneous melanomas from 345 patients. The correlation between osteopontin expression and several histologic markers for melanoma was assessed by using the Chi-square test and the Le directional test. The impact of osteopontin expression on recurrence-free survival (RFS) and disease-specific survival (DSS) of patients with melanoma was examined using Cox regression and Kaplan-Meier analyses. The impact of increasing osteopontin expression on sentinel lymph node (SLN) metastasis was assessed using logistic regression analysis. High osteopontin expression was associated with increased tumor thickness (P = .037), Clark level (P = .035), and mitotic index (P = .046). Kaplan-Meier analysis demonstrated an association between osteopontin expression and reduced RFS (P < .03) and DSS (P = .05). Multivariate Cox regression analysis demonstrated that high osteopontin immunostaining had an independent impact on the DSS of this melanoma cohort (P = .049). In addition, osteopontin expression was significantly predictive of SLN metastasis (P = .009) and SLN burden, as assessed by the mean number of SLN metastases (P = .0025). Multivariate logistic regression analysis demonstrated an independent role for osteopontin expression in predicting SLN status (P = .0062). The current results validated the role of osteopontin as an independent prognostic marker for melanoma and provided new evidence for its predictive role in melanoma lymph node metastasis.

Rangel J ，Nosrati M ，Torabian S ，Shaikh L ，Leong SP ，Haqq C ，Miller JR 3rd ，Sagebiel RW ，Kashani-Sabet M ... -  《CANCER》

Prognostic significance of nuclear receptor coactivator-3 overexpression in primary cutaneous melanoma.

Rangel J ，Torabian S ，Shaikh L ，Nosrati M ，Baehner FL ，Haqq C ，Leong SP ，Miller JR 3rd ，Sagebiel RW ，Kashani-Sabet M ... -  《-》

Novel role for RGS1 in melanoma progression.

Rangel J ，Nosrati M ，Leong SP ，Haqq C ，Miller JR 3rd ，Sagebiel RW ，Kashani-Sabet M ... -  《-》

Sentinel lymph node micrometastasis and other histologic factors that predict outcome in patients with thicker melanomas.

Cherpelis BS ，Haddad F ，Messina J ，Cantor AB ，Fitzmorris K ，Reintgen DS ，Fenske NA ，Glass LF ... -  《JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY》

Comparison of metallothionein-overexpression with sentinel lymph node biopsy as prognostic factors in melanoma.

Weinlich G ，Topar G ，Eisendle K ，Fritsch PO ，Zelger B ... -  《JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY》