Antifungal susceptibility of Cryptococcus neoformans isolates in HIV-infected patients to fluconazole, itraconazole and voriconazole in Spain: 1994-1996 and 1997-2005.

The antifungal drug susceptibility of 70 Cryptococcus neoformans isolates obtained in Spain from 1994 to 1996 (23 isolates) and from 1997 to 2005 (47 isolates) was investigated. The MICs of fluconazole, itraconazole and voriconazole were determined by the modified Clinical and Laboratory Standards Institute (CLSI; formerly National Committee for Clinical Laboratory Standards) broth microdilution method. The MIC(50) and MIC(90) for itraconazole and voriconazole did not change significantly from 1994 to 2005. The MIC(50) of fluconazole remained stable and the MIC(90) decreased by 2 log(2) dilution in the isolates collected from 1997 to 2005. We conclude that the in vitro resistance to fluconazole decreased over an 11-year period. In addition, a tendency for the development of possible cross-resistance between the three triazoles was observed.

Aller AI ，Claro R ，Castro C ，Serrano C ，Colom MF ，Martín-Mazuelos E ... -  《-》

Activity of voriconazole, itraconazole, fluconazole and amphotericin B in vitro against 1763 yeasts from 472 patients in the voriconazole phase III clinical studies.

Johnson E ，Espinel-Ingroff A ，Szekely A ，Hockey H ，Troke P ... -  《INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS》

[Investigation of in vitro activities of fluconazole, itraconazole and voriconazole against clinical isolates of Blastoschizomyces capitatus (Geotrichum capitatum) by two different methods].

Sancak B ，Alp S ，Hasçelik G ，Arikan S ... -  《MIKROBIYOLOJI BULTENI》

Trends in antifungal drug susceptibility of Cryptococcus neoformans isolates in the United States: 1992 to 1994 and 1996 to 1998.

Brandt ME ，Pfaller MA ，Hajjeh RA ，Hamill RJ ，Pappas PG ，Reingold AL ，Rimland D ，Warnock DW ，Cryptococcal Disease Active Surveillance Group ... -  《-》

Cryptococcus neoformans serotype A and Cryptococcus gattii serotype B isolates differ in their susceptibilities to fluconazole and voriconazole.

Khan ZU ，Randhawa HS ，Chehadeh W ，Chowdhary A ，Kowshik T ，Chandy R ... -  《-》