Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells.

Neuregulin-1 (NRG-1) is expressed in vascular endothelial cells, and its receptors are localized to the underlying smooth muscle cells. However, the role of NRG-1 in vascular function and injury is largely unknown. First, the expression of NRG-1 and its receptors (erbB receptors) was analyzed after balloon injury to the rat carotid artery. NRG-1 and erbB expression levels were low in uninjured vessels; however, NRG-1 and erbB4 were upregulated following injury. We then examined the effect of NRG-1 on neointimal formation following balloon injury. NRG-1 was administered by tail-vein injection prior to injury and every 2 days following injury. Two weeks after injury, NRG-1-treated animals demonstrated a 50% reduction in lesion size compared with controls receiving the vehicle. To examine possible mechanisms for NRG-1 action, we examined its effects on vascular smooth muscle cell (VSMC) function. Rat VSMC cultures were pretreated with NRG-1 for 24 h and then stimulated with platelet-derived growth factor. NRG-1 significantly decreased platelet-derived growth factor-stimulated VSMC proliferation and migration. These findings suggest that NRG-1 may be a novel therapeutic candidate for the treatment of restenosis and atherosclerosis.

Clement CM ，Thomas LK ，Mou Y ，Croslan DR ，Gibbons GH ，Ford BD ... -  《JOURNAL OF VASCULAR RESEARCH》

Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation.

Yang X ，Thomas DP ，Zhang X ，Culver BW ，Alexander BM ，Murdoch WJ ，Rao MN ，Tulis DA ，Ren J ，Sreejayan N ... -  《-》

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling.

Razuvaev A ，Henderson B ，Girnita L ，Larsson O ，Axelson M ，Hedin U ，Roy J ... -  《JOURNAL OF VASCULAR SURGERY》

Inhibition of vascular smooth muscle cell proliferation and neointimal formation in injured arteries by a novel, oral mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor.

Gennaro G ，Ménard C ，Michaud SE ，Deblois D ，Rivard A ... -  《-》

Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation.

Francis DJ ，Parish CR ，McGarry M ，Santiago FS ，Lowe HC ，Brown KJ ，Bingley JA ，Hayward IP ，Cowden WB ，Campbell JH ，Campbell GR ，Chesterman CN ，Khachigian LM ... -  《-》