Effects of methylphenidate on leptin and appetite in children with attention-deficit hyperactivity disorder: an open label trial.

Appetite suppression is one of the most common side effects of methylphenidate (MPH), which is used for treatment of attention-deficit hyperactivity disorder (ADHD). Relation of appetite and leptin is well known but there is no report regarding MPH use and leptin. In this study we compared the baseline leptin levels of ADHD children with the controls and studied the interaction between MPH and leptin-insulin level in ADHD children under MPH treatment. The major finding of this study is that at a total daily dose of 0.6 mg/kg short-acting MPH treatment, one does not observe significant side effects related to appetite suppression and metabolic features as measured via body mass index, insulin and leptin levels. Thus this range seems to be safe in developing ADHD children with minimum side effects regarding appetite for short-term treatment.

Işeri E ，Kiliç BG ，Senol S ，Karabacak NI ... -  《methods and findings in experimental and clinical pharmacology》

Effects of methylphenidate on quality of life in children with both developmental coordination disorder and ADHD.

Flapper BC ，Schoemaker MM 《DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY》

No elevated genomic damage in children and adolescents with attention deficit/hyperactivity disorder after methylphenidate therapy.

Walitza S ，Kämpf K ，Artamonov N ，Romanos M ，Gnana Oli R ，Wirth S ，Warnke A ，Gerlach M ，Stopper H ... -  《TOXICOLOGY LETTERS》

Evaluation of risks associated with short- and long-term psychostimulant therapy for treatment of ADHD in children.

Kociancic T ，Reed MD ，Findling RL 《Expert Opinion On Drug Safety》

Long-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trials.

Findling RL ，Wigal SB ，Bukstein OG ，Boellner SW ，Abikoff HB ，Turnbow JM ，Civil R ... -  《-》