Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.

Previous studies have shown improvement in left ventricular function after intracoronary injection of autologous cells derived from bone marrow (BMC) in the acute phase of myocardial infarction. We designed a randomized, controlled trial to further investigate the effects of this treatment. Patients with acute ST-elevation myocardial infarction of the anterior wall treated with percutaneous coronary intervention were randomly assigned to the group that underwent intracoronary injection of autologous mononuclear BMC or to the control group, in which neither aspiration nor sham injection was performed. Left ventricular function was assessed with the use of electrocardiogram-gated single-photon-emission computed tomography (SPECT) and echocardiography at baseline and magnetic resonance imaging (MRI) 2 to 3 weeks after the infarction. These procedures were repeated 6 months after the infarction. End points were changes in the left ventricular ejection fraction (LVEF), end-diastolic volume, and infarct size. Of the 50 patients assigned to treatment with mononuclear BMC, 47 underwent intracoronary injection of the cells at a median of 6 days after myocardial infarction. There were 50 patients in the control group. The mean (+/-SD) change in LVEF, measured with the use of SPECT, between baseline and 6 months after infarction for all patients was 7.6+/-10.4 percentage points. The effect of BMC treatment on the change in LVEF was an increase of 0.6 percentage point (95% confidence interval [CI], -3.4 to 4.6; P=0.77) on SPECT, an increase of 0.6 percentage point (95% CI, -2.6 to 3.8; P=0.70) on echocardiography, and a decrease of 3.0 percentage points (95% CI, 0.1 to -6.1; P=0.054) on MRI. The two groups did not differ significantly in changes in left ventricular end-diastolic volume or infarct size and had similar rates of adverse events. With the methods used, we found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.

Lunde K ，Solheim S ，Aakhus S ，Arnesen H ，Abdelnoor M ，Egeland T ，Endresen K ，Ilebekk A ，Mangschau A ，Fjeld JG ，Smith HJ ，Taraldsrud E ，Grøgaard HK ，Bjørnerheim R ，Brekke M ，Müller C ，Hopp E ，Ragnarsson A ，Brinchmann JE ，Forfang K ... -  《-》

Administration of intracoronary bone marrow mononuclear cells on chronic myocardial infarction improves diastolic function.

Yao K ，Huang R ，Qian J ，Cui J ，Ge L ，Li Y ，Zhang F ，Shi H ，Huang D ，Zhang S ，Sun A ，Zou Y ，Ge J ... -  《-》

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel

Dill T ，Schächinger V ，Rolf A ，Möllmann S ，Thiele H ，Tillmanns H ，Assmus B ，Dimmeler S ，Zeiher AM ，Hamm C ... -  《-》

Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial.

Meyer GP ，Wollert KC ，Lotz J ，Steffens J ，Lippolt P ，Fichtner S ，Hecker H ，Schaefer A ，Arseniev L ，Hertenstein B ，Ganser A ，Drexler H ... -  《-》

Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracor

Tendera M ，Wojakowski W ，Ruzyłło W ，Chojnowska L ，Kepka C ，Tracz W ，Musiałek P ，Piwowarska W ，Nessler J ，Buszman P ，Grajek S ，Breborowicz P ，Majka M ，Ratajczak MZ ，REGENT Investigators ... -  《-》