Precursor B-cell acute lymphoblastic leukemia presenting with hemophagocytic lymphohistiocytosis.

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome which can be an inherited congenital disorder or can develop secondary to malignancy, infection, or autoimmune disease. Secondary HLH due to malignancy occurs most commonly with T or NK-cell lymphoid neoplasms. HLH with B-cell malignancies is less common and HLH has rarely been described in association with precursor B-cell acute lymphoblastic leukemia (B-ALL). We report three cases of HLH associated with B-ALL and review 17 cases of ALL-associated HLH previously reported in the literature.

O'Brien MM ，Lee-Kim Y ，George TI ，McClain KL ，Twist CJ ，Jeng M ... -  《-》

Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia.

We report a case of a child with precursor-B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL-directed therapy and HLH-directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post-transplant and in remission from leukemia and HLH.

Kelly C ，Salvi S ，McClain K ，Hayani A ... -  《-》

Pediatric acute lymphoblastic leukemia complicated by secondary hemophagocytic lymphohistiocytosis.

Hemophagocytic lymphohistiocytosis (HLH) may be familial or secondary to infections, malignancies, metabolic disorders. Infectious causes are mostly viral and EBV is the mostly frequently seen etiologic agent. In this case, we report a child with acute lymphoblastic leukemia (ALL), who had three episodes of secondary HLH, possibly due to two different viral etiologies, namely CMV and RSV together with her malignancy, during her induction-consolidation treatment.

Devecioglu O ，Anak S ，Atay D ，Aktan P ，Devecioglu E ，Ozalp B ，Saribeyoglu E ... -  《-》

Parvovirus B19-associated hemophagocytic lymphohistiocytosis in a child with precursor B-cell acute lymphoblastic leukemia under maintenance chemotherapy.

Matsubara K ，Uchida Y ，Wada T ，Iwata A ，Yura K ，Kamimura K ，Nigami H ，Fukaya T ... -  《-》

Malignancy-associated hemophagocytic lymphohistiocytosis in pediatric cases: a multicenter study from Turkey.

Celkan T ，Berrak S ，Kazanci E ，Ozyürek E ，Unal S ，Uçar C ，Yilmaz S ，Gürgey A ... -  《TURKISH JOURNAL OF PEDIATRICS》