Safety and feasibility of breast conserving therapy in Indian women: two decades of experience at Tata Memorial Hospital.

The NIH consensus statement on the management of breast cancer has highlighted the paucity of outcome data in non-Caucasian women. Treatment outcome and factors determining it in a large cohort of ethnic Indian women treated with breast conserving therapy (BCT) at Tata Memorial Hospital are reported here. During 1980-2000, 1,022 pathological Stage I/II breast cancer patients (median age 43 years) underwent BCT (wide excision, complete axillary clearance, whole breast radiotherapy with 6 MV photons plus tumor bed boost, +/-systemic therapy). Median pathological tumor size was 3 cm (1-5 cm). Axillary node metastases were found in 39% women. Of the 938 patients with IDC, 70% were Grade III and in patients where receptor status was known, 209/625 (33%) were ER positive and 245/591 (41%) were PR positive. The 5- and 10-year actuarial overall survival was 87% and 77% and disease-free survival was 76% and 68%, respectively. Actuarial 5-year local and locoregional control rates were 91% and 87%, respectively. Cosmesis was good or excellent in 78% women. Independent adverse prognostic factors for local recurrence were, age<40 years, axillary node metastasis, lymphovascular invasion (LVI), and adjuvant systemic therapy; for locoregional recurrence-inner quadrant tumor, axillary node metastasis, and LVI; for survival-LVI and axillary node metastasis. Compared to Caucasians, these Indian women undergoing BCT were younger, had larger, higher grade, and receptor negative tumors. Comparable local control and survival was obtained by using stringent quality assurance in the diagnostic and therapeutic protocol. BCT, a resource intense treatment is safe for selected and motivated patients undergoing treatment at centers with adequate facilities and expertise even in countries with limited resources.

Dinshaw KA ，Sarin R ，Budrukkar AN ，Shrivastava SK ，Deshpande DD ，Chinoy RF ，Badwe R ，Hawaldar R ... -  《JOURNAL OF SURGICAL ONCOLOGY》

Profile of prognostic factors in 1022 Indian women with early-stage breast cancer treated with breast-conserving therapy.

Dinshaw KA ，Budrukkar AN ，Chinoy RF ，Sarin R ，Badwe R ，Hawaldar R ，Shrivastava SK ... -  《INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS》

Prognostic factors in node negative premenopausal women treated with breast conserving therapy without adjuvant systemic therapy.

Budrukkar AN ，Sarin R ，Chinoy RF ，Badwe R ，Shrivastava SK ，Dinshaw KA ... -  《BREAST》

Treatment results and prognostic factors of early breast cancer treated with a breast conserving operation and radiotherapy.

Kim KJ ，Huh SJ ，Yang JH ，Park W ，Nam SJ ，Kim JH ，Lee JH ，Kang SS ，Lee JE ，Kang MK ，Park YJ ，Nam HR ... -  《JAPANESE JOURNAL OF CLINICAL ONCOLOGY》

Selecting breast cancer patients with T1-T2 tumors and one to three positive axillary nodes at high postmastectomy locoregional recurrence risk for adjuvant radiotherapy.

Truong PT ，Olivotto IA ，Kader HA ，Panades M ，Speers CH ，Berthelet E ... -  《INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS》