Endothelial nitric oxide synthase polymorphism is not associated with placental abruption in Finnish women.

To study whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) affects individual susceptibility to the development of placental abruption during pregnancy. One hundred and sixteen pregnant women with placental abruption and 113 healthy controls were genotyped for Glu298Asp polymorphism in the eNOS gene. Chi-square analysis was used to assess the differences in genotype and allele frequencies between the two groups. A statistically similar allelic distribution of eNOS Glu298Asp polymorphism was observed in the two groups, with the frequency of the variant G allele being 66.8% in the abruption group and 68.1% in the control group (OR 0.94, 95% CI: 0.64-1.39; p = 0.76). The genotype distribution of the eNOS polymorphism was also found to be statistically similar (p = 0.72). The observed genotype data in subjects from eastern Finland suggest that the Glu298Asp polymorphism of the eNOS gene does not contribute to placental abruption in this population.

Toivonen S ，Keski-Nisula L ，Romppanen EL ，Helisalmi S ，Punnonen K ，Heinonen S ... -  《FETAL DIAGNOSIS AND THERAPY》

Endothelial nitric oxide synthase polymorphism in preeclampsia.

We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia. The study involved 132 preeclamptic and 113 healthy control pregnant women who were genotyped for the Glu298Asp polymorphism in the eNOS gene. Chi(2) analysis was used to assess genotype and allele frequency differences between preeclamptic women and controls. A statistically similar allelic distribution of eNOS Glu298Asp polymorphism was observed in the two groups, with the frequency of the variant G allele being 74.6% in the preeclampsia group and 67.7% in the control group (P = .091; odds ratio 1.40, 95% confidence interval 0.95, 2.01). Accordingly, the genotype distribution of the NOS polymorphism in the preeclamptic and control groups was found to be similar (P = .233). These genotype data in subjects from eastern Finland were not suggestive of an important contribution of the Glu298Asp polymorphism in the NOS gene on preeclampsia across populations. However, the observed association between the G allele and disease risk, of borderline significance, may imply that other polymorphism(s) in the gene may modify disease risk.

Häkli T ，Romppanen EL ，Hiltunen M ，Helisalmi S ，Punnonen K ，Heinonen S ... -  《journal of the society for gynecologic investigation》

M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women.

Jääskeläinen E ，Toivonen S ，Romppanen EL ，Helisalmi S ，Keski-Nisula L ，Punnonen K ，Heinonen S ... -  《PLACENTA》

Low-activity haplotype of the microsomal epoxide hydrolase gene is protective against placental abruption.

Toivonen S ，Romppanen EL ，Hiltunen M ，Helisalmi S ，Keski-Nisula L ，Punnonen K ，Heinonen S ... -  《journal of the society for gynecologic investigation》

The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.

Yoshimura T ，Yoshimura M ，Tabata A ，Yasue H ，Okamura H ... -  《-》