Similar long-term results of breast-conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast: The University of Pennsylvania experience.

The objective of the current study was to determine the long-term results of breast-conservation treatment in women with early-stage, invasive lobular carcinoma of the breast. Between 1977 and 1995, 1093 women with Stage I and II invasive ductal carcinoma of the breast and 55 women with invasive lobular carcinoma of the breast underwent lumpectomy, axillary lymph node dissection, and radiation treatment. Overall, 49% of the women received adjuvant systemic therapy (chemotherapy and/or hormones). The median age was 52 years for patients in the invasive ductal group and 54 years for patients in the invasive lobular group. The median follow-up was 8.7 years and 10.2 years for patients in the invasive ductal and invasive lobular groups, respectively. A comparison of patients who had invasive lobular carcinoma with patients who had invasive ductal carcinoma showed no difference in the 10-year actuarial rates of overall survival (85% vs. 79%, respectively; P = 0.73), cause-specific survival (93% vs. 84%, respectively; P = 0.85), or freedom from distant metastases (81% vs. 80%, respectively; P = 0.76). The 10-year rates of local failure were 18% for patients with invasive lobular carcinoma and 12% for patients with invasive ductal carcinoma (P = 0.24), and the 10-year rates of contralateral breast carcinoma development for the 2 groups were 12% and 8%, respectively (P = 0.40). Breast-conservation treatment yielded similar long-term results for women with early-stage, invasive lobular carcinoma and women with the more prevalent invasive ductal carcinoma.

Santiago RJ ，Harris EE ，Qin L ，Hwang WT ，Solin LJ ... -  《CANCER》

Outcomes of breast-conservation therapy for invasive lobular carcinoma are equivalent to those for invasive ductal carcinoma.

Vo TN ，Meric-Bernstam F ，Yi M ，Buchholz TA ，Ames FC ，Kuerer HM ，Bedrosian I ，Hunt KK ... -  《AMERICAN JOURNAL OF SURGERY》

Therapeutic options and results for the management of minimally invasive carcinoma of the breast: influence of axillary dissection for treatment of T1a and T1b lesions.

White RE ，Vezeridis MP ，Konstadoulakis M ，Cole BF ，Wanebo HJ ，Bland KI ... -  《JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS》

[Breast-conserving treatment for early invasive lobular breast cancer: 15 years results].

Fodor J ，Sulyok Z ，Polgár C ，Major T ，Tóth J ，Németh G ... -  《-》

Long-term cosmesis after lumpectomy and brachytherapy in the management of carcinoma of the previously irradiated breast.

Trombetta M ，Julian TB ，Werts DE ，McWilliams W ，Kim Y ，Miften M ，Parda D ... -  《-》