Osteosarcoma of the pelvis in children and young adults: the St. Jude Children's Research Hospital experience.

Pelvic osteosarcomas are difficult to resect. The authors reviewed their institution's experience with patients who had such tumors to characterize the patients' clinical findings and to assess the impact of surgical resection on outcome. A review was conducted of the records from patients with pelvic osteosarcoma who were treated at the authors' institution between January, 1970 and March, 2004. Among 442 patients with osteosarcoma, 19 patients (4%) had high-grade tumors arising in the pelvic bones, including the ilium in 15 patients, the pubis in 2 patients, and the sacrum in 2 patients. The median patient age at diagnosis was 16.8 years. Four tumors were secondary to radiation therapy. Five patients had metastases in the lung (n = 4 patients) or bone (n = 1 patient) at diagnosis. Ten tumors were chondroblastic. The median greatest tumor dimension for the 13 tumors with known size was 10 cm. Ten patients had unresectable pelvic tumors, and 9 patients underwent hemipelvectomy (2 internal and 7 external); complete resection with negative margins was achieved in 5 patients. Four patients survived, including one patient who survived with disease. Of the three patients who survived disease-free, one patient underwent complete resection, one patient underwent incomplete resection (nonviable tumor at the soft tissue margin) with a good response to chemotherapy, and one patient with a sacral tumor underwent radiotherapy only for local control. Of the 9 patients who underwent resection, 7 experienced disease recurrence (n = 5 patients) or progression (n = 2 patients) at distant sites and died. All patients with metastatic disease at diagnosis died. Pelvic osteosarcomas often were large and unresectable. A high propensity for metastasis contributed to the poor outcome of patients with pelvic osteosarcoma. New therapeutic approaches are needed.

Saab R ，Rao BN ，Rodriguez-Galindo C ，Billups CA ，Fortenberry TN ，Daw NC ... -  《CANCER》

Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience.

Daw NC ，Mahmoud HH ，Meyer WH ，Jenkins JJ ，Kaste SC ，Poquette CA ，Kun LE ，Pratt CB ，Rao BN ... -  《CANCER》

Prognostic factors for patients with sarcomas of the pelvic bones.

Kawai A ，Healey JH ，Boland PJ ，Lin PP ，Huvos AG ，Meyers PA ... -  《CANCER》

Clinical outcomes of 54 pelvic osteosarcomas registered by Japanese musculoskeletal oncology group.

To determine the clinical outcomes in patients with pelvic osteosarcoma, we reviewed the experience with 54 pelvic osteosarcoma patients. Thirty-five patients underwent surgical treatment with 30 undergoing limb salvage procedures and 5 requiring hemipelvectomies. Oncological outcome was continuously disease free in 12 cases, no evidence of disease in 3, alive with disease in 3, died of disease in 34 and died of other causes in 2. The 5-year survival rate was 29.5%. For the patients who underwent surgery, statistically significant prognostic factors were chemotherapy, surgical margin, tumor location in sacrum, efficacy of chemotherapy, local recurrence, metastasis and treatment for metastases. With univariate analysis, local recurrence, surgical margin and tumors resected from the sacrum were significant prognostic factors for metastasis. Surgical margin, tumor resected from sacrum and metastasis were significant prognostic factors for local recurrence. With regard to postoperative functional mobility, patients with tumors resected from the sacrum exhibited poorer functional mobility when compared with other sites. Patients with tumors located in the sacrum had worse prognosis, and significant prognostic factor for local recurrence and metastasis. Treatment of pelvic osteosarcoma especially located in the sacrum requires new approaches and further improvements in order to ensure successful outcomes.

Matsuo T ，Sugita T ，Sato K ，Hotta T ，Tsuchiya H ，Shimose S ，Kubo T ，Ochi M ... -  《ONCOLOGY》

Osteosarcoma of the pelvis: outcome analysis of surgical treatment.

Fuchs B ，Hoekzema N ，Larson DR ，Inwards CY ，Sim FH ... -  《-》