Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats.

Repeated maternal separation of rat pups during the early postnatal period may affect brain-derived neurotrophic factor (BDNF) or neurons in brain areas that are compromised by chronic stress. In the present study, a highly significant increase in hippocampal BDNF protein concentration was found in adult rats that as neonates had been subjected to 180 min of daily separation compared with handled rats separated for 15 min daily. BDNF protein was unchanged in the frontal cortex and hypothalamus/paraventricular nucleus. Expression of BDNF mRNA in the CA1, CA3, or dentate gyrus of the hippocampus or in the paraventricular hypothalamic nucleus was not affected by maternal separation. All animals displayed similar behavioral patterns in a forced-swim paradigm, which did not affect BDNF protein concentration in the hippocampus or hypothalamus. Repeated administration of bromodeoxyuridine revealed equal numbers of surviving, newly generated granule cells in the dentate gyrus of adult rats from the 15 min or 180 min groups. The age-dependent decline in neurogenesis from 3 months to 7 months of age did not differ between the groups. Insofar as BDNF can stimulate neurogenesis and repair, we propose that the elevated hippocampal protein concentration found in maternally deprived rats might be a compensatory reaction to separation during the neonatal period, maintaining adult neurogenesis at levels equal to those of the handled rats.

Greisen MH ，Altar CA ，Bolwig TG ，Whitehead R ，Wörtwein G ... -  《JOURNAL OF NEUROSCIENCE RESEARCH》

Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus.

Hattiangady B ，Rao MS ，Shetty GA ，Shetty AK ... -  《EXPERIMENTAL NEUROLOGY》

Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.

Xu Y ，Ku B ，Cui L ，Li X ，Barish PA ，Foster TC ，Ogle WO ... -  《BRAIN RESEARCH》

Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats.

Marmigère F ，Givalois L ，Rage F ，Arancibia S ，Tapia-Arancibia L ... -  《HIPPOCAMPUS》

Perinatal undernutrition modifies cell proliferation and brain-derived neurotrophic factor levels during critical time-windows for hypothalamic and hippocampal development in the male rat.

Coupé B ，Dutriez-Casteloot I ，Breton C ，Lefèvre F ，Mairesse J ，Dickes-Coopman A ，Silhol M ，Tapia-Arancibia L ，Lesage J ，Vieau D ... -  《-》