The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.

The organization of intracellular compartments and the transfer of components between them are central to the correct functioning of mammalian cells. Proteins and lipids are transferred between compartments by the formation, movement and subsequent specific fusion of transport intermediates. These vesicles and membrane clusters must be coupled to the cytoskeleton and to motor proteins that drive motility. Anterograde ER (endoplasmic reticulum)-to-Golgi transport, and the converse step of retrograde traffic from the Golgi to the ER, are now known to involve coupling of membranes to the microtubule cytoskeleton. Here we shall discuss our current understanding of the mechanisms that link membrane traffic in the early secretory pathway to the microtubule cytoskeleton in mammalian cells. Recent data have also provided molecular detail of functional co-ordination of motor proteins to specify directionality, as well as mechanisms for regulating motor activity by protein phosphorylation.

Palmer KJ ，Watson P ，Stephens DJ 《biochemical society symposium》

Actin microfilaments facilitate the retrograde transport from the Golgi complex to the endoplasmic reticulum in mammalian cells.

Valderrama F ，Durán JM ，Babià T ，Barth H ，Renau-Piqueras J ，Egea G ... -  《TRAFFIC》

Dynein supports motility of endoplasmic reticulum in the fungus Ustilago maydis.

Wedlich-Söldner R ，Schulz I ，Straube A ，Steinberg G ... -  《MOLECULAR BIOLOGY OF THE CELL》

Membrane cycling between the ER and Golgi apparatus and its role in biosynthetic transport.

Lippincott-Schwartz J 《-》

Interaction of early secretory pathway and Golgi membranes with microtubules and microtubule motors.

Fokin AI ，Brodsky IB ，Burakov AV ，Nadezhdina ES ... -  《-》