Suicidal ideation and bipolar-II depression symptoms.

The FDA issued a warning about a possible risk of suicidal behaviour related to 'newer' antidepressants. Suicidal behaviour is common in bipolar-II (BP-II) depression, which is frequent in outpatients, and often mixed (i.e. it has concurrent hypomanic symptoms). The study aim was to find major depressive episode (MDE) and intra-MDE hypomanic symptoms associated with suicidal ideation. A total of 374 consecutive BP-II MDE outpatients were interviewed by the structured clinical interview for DSM-IV (SCID), the hypomania interview guide, and the family history screen. Suicidal ideation was present in 52.6%. Suicidal ideation and lower GAF (meaning more severity), more persistent MDE symptoms, more melancholic depressions were significantly associated. Multiple logistic regression of suicidal ideation versus MDE symptoms and intra-MDE hypomanic symptoms found, as significant independent predictors, decreased self-esteem, racing/crowded thoughts, psychomotor agitation. As expected, suicidal ideation and depression severity were associated. Racing/crowded thoughts and psychomotor agitation were independent predictors of suicidal ideation. While cross-sectional associations cannot show a causal association, some evidence from prospective studies supports the direction of the association. As BP-II depression is common and often mixed in outpatients, clinicians should assess intra-MDE racing/crowded thoughts and psychomotor agitation, as antidepressants alone may worsen these symptoms, and this may induce or increase suicidal behaviour. Mood stabilizing agents may be needed to control these excitement symptoms before using antidepressants.

Benazzi F 《HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL》

Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy.

Akiskal HS ，Benazzi F ，Perugi G ，Rihmer Z ... -  《JOURNAL OF AFFECTIVE DISORDERS》

Symptoms of depression as possible markers of bipolar II disorder.

Benazzi F 《PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY》

Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population?

Akiskal HS ，Benazzi F 《JOURNAL OF AFFECTIVE DISORDERS》

Family history validation of a definition of mixed depression.

Benazzi F 《COMPREHENSIVE PSYCHIATRY》