Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging.

To retrospectively assess the prognostic meaning of tumor characteristics depicted on pretreatment magnetic resonance (MR) images for local outcome in supraglottic squamous cell carcinoma treated with definitive radiation therapy. Pretreatment MR images acquired in 84 patients with supraglottic carcinoma treated with curative radiation therapy were reviewed for tumor involvement of laryngeal sites including glottis, subglottis, pre-epiglottic space, laryngeal cartilages, and hypopharynx, and for extralaryngeal extension. The volume of each tumor was estimated, and mean tumor volume was calculated for the group of tumors in each T staging category. Results of univariate analysis showed MR imaging-determined primary tumor volume (P =.03), involvement of pre-epiglottic space (P =.008), abnormal signal intensity in thyroid cartilage (P =.04), and extralaryngeal extension beyond thyroid and/or cricoid cartilage (P =.02) to be significant predictors of local control rate. Results of multivariate analysis with the Cox regression model confirmed statistical significance for invasion of pre-epiglottic space (P =.004) and for abnormal signal intensities in thyroid cartilage adjacent to the anterior commissure (P =.04) and in cricoid cartilage (P =.01). Five-year local control rates were calculated from the regression coefficients of three independent MR imaging prognostic factors, and three prognostic groups were identified on the basis of these control rates. The 5-year local control rate in the high-risk group was 35%, significantly lower than the rates in the intermediate- and low-risk groups (60% and 89%, respectively; P =.002). MR imaging-determined pre-epiglottic space involvement and abnormal signal intensities in the thyroid cartilage adjacent to the anterior commissure and/or the cricoid cartilage are strong predictors of local outcome in supraglottic carcinoma treated with definitive radiation therapy.

Ljumanović R ，Langendijk JA ，Schenk B ，Van Wattingen M ，Knol DL ，Leemans CR ，Castelijns JA ... -  《RADIOLOGY》

MR imaging predictors of local control of glottic squamous cell carcinoma treated with radiation alone.

To retrospectively evaluate the prognostic significance of magnetic resonance (MR) imaging-determined tumor parameters, especially the presence of cartilage invasion, regarding local control of glottic squamous cell carcinoma treated with radiation therapy (RT) alone. The study was performed with the approval of our institutional review board; direct patient consent was waived. Pretreatment MR images of 118 patients aged 41-86 years (110 men, eight women) with glottic carcinoma treated with RT alone were reviewed for tumor involvement of specific laryngeal anatomic subsites (including laryngeal cartilage), tumor volume, and extralaryngeal tumor spread; these findings were compared with local control. Local control was defined as absence of a recurrence at the primary site for 2 years. Statistical significance of differences between curves for local control estimated with the Kaplan-Meier method was tested with log-rank test. Results of univariate analysis showed all MR imaging-determined parameters to be significant predictors of local control rate, compared with clinical parameters where T classification and vocal cord mobility were the only significant parameters associated with local control. Multivariate analysis (Cox regression model) of clinical and radiologic parameters revealed that hypopharyngeal extension (P=.04) and intermediate T2 signal intensity (SI) in cartilage similar to tumor SI (P<.001) were independent prognostic factors with regard to local control. Intermediate T2 SI in cartilage, which may suggest cartilage invasion, and hypopharyngeal extension of tumor, predict greater likelihood of local failure, whereas high T2 SI, which may suggest inflammatory tissue in cartilage, predicts lower likelihood of local failure.

Ljumanovic R ，Langendijk JA ，van Wattingen M ，Schenk B ，Knol DL ，Leemans CR ，Castelijns JA ... -  《RADIOLOGY》

Pathological validation of supracricoid partial laryngectomy in laryngeal cancer.

Sun DI ，Cho KJ ，Cho JH ，Joo YH ，Jung CK ，Kim MS ... -  《-》

Predictive value of MR imaging-dependent and non-MR imaging-dependent parameters for recurrence of laryngeal cancer after radiation therapy.

Castelijns JA ，van den Brekel MW ，Smit EM ，Tobi H ，van Wagtendonk FW ，Golding RP ，Venema HW ，van Schaik C ，Snow GB ... -  《RADIOLOGY》

Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy.

Suoglu Y ，Guven M ，Kiyak E ，Enoz M ... -  《-》