Effects of ochratoxin a on oxidative damage in rat kidney: protective role of melatonin.

Epidemiological studies indicate that ochratoxin A (OTA) may be involved in the pathogenesis of different forms of human nephropathies. Melatonin (MEL) displays antioxidant and free radical scavenger properties. In the present study, the effect of MEL on the oxidative stress induced by OTA administration in rats was investigated. Three groups of eight rats each were used: control, OTA (289 micro g kg(-1) day(-1)) and OTA + MEL (OTA, 289 micro g kg(-1) day(-1); MEL, 10 mg kg(-1) day(-1)), with treatment at two different time periods during the same day. After 4 weeks of treatment, the levels of lipid peroxidation (LPO) and the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured in homogenates of kidney. In OTA-treated rats, the levels of LPO and the activities of GSHPx and SOD were significantly decreased compared with controls. In OTA + MEL-treated rats, SOD, GSHPx and catalase activities and LPO levels were not changed significantly in comparison with controls.

Ozçelik N ，Soyöz M ，Kilinç I 《JOURNAL OF APPLIED TOXICOLOGY》

Protective role of melatonin and coenzyme Q10 in ochratoxin A toxicity in rat liver and kidney.

Sutken E ，Aral E ，Ozdemir F ，Uslu S ，Alatas O ，Colak O ... -  《INTERNATIONAL JOURNAL OF TOXICOLOGY》

Protective role of melatonin in ochratoxin a toxicity in rat heart and lung.

Okutan H ，Aydin G ，Ozcelik N 《JOURNAL OF APPLIED TOXICOLOGY》

Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney.

Meki AR ，Hussein AA 《COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY》

The effects of ochratoxin A on lipid peroxidation and antioxidant enzymes: a protective role of melatonin.

Soyöz M ，Ozçelik N ，Kilinç I ，Altuntaş I ... -  《CELL BIOLOGY AND TOXICOLOGY》