Effect of oral administration of Arabic gum on cisplatin-induced nephrotoxicity in rats.

It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. It has also recently shown a powerful antioxidant effect through scavenging superoxide anions. In this study we utilized a rat model of cisplatin (CP)-induced nephrotoxicity to determine its peak time following (1, 2, 5, and 7 days) of a single CP (7.5 mg/kg, i.p.) injection. Also, a possible protective effect of cotreatment with AG (7.5 g/kg/day p.o.) on CP-induced nephrotoxicity was investigated. Biochemical as well as histological assessments were carried out. CP-induced nephrotoxicity was manifested by significant elevations of the functional parameters blood urea, serum creatinine, and kidney/body weight ratio. Maximum toxic effects of CP were observed 5 days after its injection, while it started after day 1 in the biochemical parameters, such as glutathione depletion in the kidney tissue with concomitant increases in lipid peroxides and platinum content. Additionally, severe necrosis and desquamation of tubular epithelial cells in renal cortex as well as interstitial nephritis were observed after 5 days in CP-treated animals. Five days after AG cotreatment with CP did not protect the kidney from the damaging effects of CP. However, it significantly reduced CP-induced lipid peroxidation. These findings suggest that lipid peroxidation is not the main cause of CP-induced nephrotoxicity but it is rather more dependent on other factors such as platinum disposition in renal interstitial tubules.

Al-Majed AA ，Abd-Allah AR ，Al-Rikabi AC ，Al-Shabanah OA ，Mostafa AM ... -  《JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY》

Protection against cisplatin-induced nephrotoxicity by Spirulina in rats.

Mohan IK ，Khan M ，Shobha JC ，Naidu MU ，Prayag A ，Kuppusamy P ，Kutala VK ... -  《CANCER CHEMOTHERAPY AND PHARMACOLOGY》

Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide.

Saleh S ，El-Demerdash E 《BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY》

Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.

Ali BH ，Al-Moundhri M ，Eldin MT ，Nemmar A ，Al-Siyabi S ，Annamalai K ... -  《-》

Naringenin attenuates cisplatin nephrotoxicity in rats.

Badary OA ，Abdel-Maksoud S ，Ahmed WA ，Owieda GH ... -  《-》