Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop.

Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification. This study analyzes 48 cases of primary cutaneous lymphoma expressing cytotoxic proteins and/or the NK cell marker, CD56. These cases were collected for a workshop of the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Task Force, to better clarify the clinical, morphologic, and phenotypic features of these uncommon tumors. Several categories with different clinical and pathologic features were delineated: 1) aggressive, CD8+, epidermotropic, cytotoxic T-cell lymphoma; 2) mycosis fungoides, cytotoxic immunophenotype variant; 3) subcutaneous panniculitis-like T-cell lymphoma; 4) NK/T-cell lymphoma, nasal type; 5) CD4+, NK cell lymphoma; 6) blastoid NK cell lymphoma; (7) intravascular NK-like lymphoma; and 8) cytotoxic, peripheral T-cell lymphoma. Our data show that primary cutaneous cytotoxic/NK cell lymphomas include distinct groups of diseases, clinically, histologically, and biologically. Because the finding of a cytotoxic phenotype often has prognostic significance, the routine use of cytotoxic markers in the diagnosis and classification of cutaneous lymphomas should be expanded.

Santucci M ，Pimpinelli N ，Massi D ，Kadin ME ，Meijer CJ ，Müller-Hermelink HK ，Paulli M ，Wechsler J ，Willemze R ，Audring H ，Bernengo MG ，Cerroni L ，Chimenti S ，Chott A ，Díaz-Pérez JL ，Dippel E ，Duncan LM ，Feller AC ，Geerts ML ，Hallermann C ，Kempf W ，Russell-Jones R ，Sander C ，Berti E ，EORTC Cutaneous Lymphoma Task Force ... -  《CANCER》

The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants.

Slater DN 《-》

Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathologic, immunophenotypic, and molecular study of 22 Asian cases according to WHO-EORTC classification.

Kong YY ，Dai B ，Kong JC ，Zhou XY ，Lu HF ，Shen L ，Du X ，Shi DR ... -  《-》

Relative frequency of the different types of cutaneous T cell and natural killer cell lymphomas in Korea based on the proposed WHO classification and the EORTC classification.

Chang SE ，Jee MS ，Kim KJ ，Choi JH ，Sung KJ ，Moon KC ，Koh JK ... -  《JOURNAL OF DERMATOLOGY》

Cutaneous T-cell and NK-cell lymphomas: the WHO-EORTC classification and the increasing recognition of specialized tumor types.

Kinney MC ，Jones D 《-》