Does colonization of Helicobacter pylori in the heterotopic gastric mucosa play a role in bleeding of Meckel's diverticulum?

Helicobacter pylori is a microorganism known to colonize in gastric type of mucosa and is associated with gastritis and peptic ulceration. The aim of the study was to determine whether colonization of H pylori in heterotopic gastric mucosa plays a role in bleeding of Meckel's diverticulum. Histopathologic slides of patients who had undergone resection of Meckel's diverticulum in recent 5 years were reexamined for the presence of H pylori in heterotopic gastric mucosa. Polimerase chain reaction (PCR) test was used to trace the genetic material of urease gene and 16s rDNA amplifications for H pylori. Thirteen of the 30 histopathologic slides of Meckel's diverticula had heterotopic gastric mucosa. Ten of the 13 patients presented with acute bleeding of the diverticula, whereas 3 of them were asymptomatic. None of the 13 gastric mucosa bearing diverticula were colonized with H pylori. PCR was unable to show any trace of genetic material for H pylori. Although the role of H pylori is well established in the gastric mucosal ulceration, its presence is not essentially required to induce "heterotopic gastritis" that may result in bleeding of the Meckel's diverticulum. .

Ergün O ，Celik A ，Akarca US ，Sen T ，Alkanat M ，Erdener A ... -  《-》

Helicobacter pylori in Meckel's diverticulum with heterotopic gastric mucosa in a population with relatively high H. pylori prevalence rate.

Chan GS ，Yuen ST ，Chu KM ，Ho JW ，Leung SY ，Ho JC ... -  《JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY》

Helicobacter pylori and Meckel's diverticula.

Finn LS ，Christie DL 《-》

Evaluation for Helicobacter pylori in Meckel's diverticulum by using real-time PCR.

Tuzun A ，Polat Z ，Kilciler G ，Turan I ，Kilic A ，Ozcan A ，Uygun A ... -  《-》

Heterotopic gastric mucosa and Helicobacter pylori infection in Meckel's diverticulum in Indian subjects.

Parikh SS ，Ranganathan S ，Prabhu SR ，Kalro RH ... -  《-》