Considerations in genetic counseling for inherited breast cancer predisposition.

Of the 190000 women estimated to have been diagnosed with breast cancer in 2001, between 5% and 10% of them are likely to have developed their disease as the result of an inherited susceptibility. Although breast cancer is a component tumor of several familial cancer predisposition syndromes, mutations in BRCA1 and BRCA2 are the most commonly identified germline changes. Recognition of hereditary breast cancer is critical to allow the implementation of appropriate treatment, screening, and prevention strategies for the affected woman and her family members. Genetic testing may play an important role in refining risk assessment, identifying individuals at risk before cancer has developed, and relieving anxiety in family members who have not inherited the predisposition.

Robson ME ，Offit K 《SEMINARS IN RADIATION ONCOLOGY》

Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations.

Casey MJ ，Synder C ，Bewtra C ，Narod SA ，Watson P ，Lynch HT ... -  《GYNECOLOGIC ONCOLOGY》

[Clinical and molecular diagnosis of inherited breast-ovarian cancer].

Chompret A 《-》

[BRCA1 and BRCA2 have reached the clinical medicine. The 10-year old finding of the genetic mutation makes it now possible to prevent breast cancer].

Loman N 《-》

Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions.

Lancaster JM ，Powell CB ，Kauff ND ，Cass I ，Chen LM ，Lu KH ，Mutch DG ，Berchuck A ，Karlan BY ，Herzog TJ ，Society of Gynecologic Oncologists Education Committee ... -  《-》