Insulin-stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes.

Sterol response element binding protein 1c (SREBP-1c) is a transcription factor that has been implicated in the regulation of expression of key lipogenic genes in hepatocytes, including fatty acid synthase (FAS) and glucokinase. In hepatocytes, insulin stimulates a rapid increase in transcription of SREBP-1c and the appearance of the SREBP-1c protein in the nucleus. SREBP-1 has also been proposed to play an important role in the induction of expression of lipogenic enzymes in adipose tissue in vivo in response to nutritional status. In this paper we have investigated the regulation of the SREBP-1 and FAS genes in adipocytes and find that while an overexpressed constitutively active SREBP-1 mutant is capable of substantially stimulating the FAS promoter, insulin appears to stimulate FAS gene expression in primary adipocytes in the absence of any apparent effect on SREBP-1 transcription. Taken together, our data suggest that insulin does not stimulate FAS gene expression through increasing SREBP-1c transcription in adipose cells.

Palmer DG ，Rutter GA ，Tavaré JM 《BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS》

Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocyte

Moldes M ，Boizard M ，Liepvre XL ，Fève B ，Dugail I ，Pairault J ... -  《-》

Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway.

Swinnen JV ，Heemers H ，Deboel L ，Foufelle F ，Heyns W ，Verhoeven G ... -  《ONCOGENE》

Leptin decreases lipogenic enzyme gene expression through modification of SREBP-1c gene expression in white adipose tissue of aging rats.

Nogalska A ，Sucajtys-Szulc E ，Swierczynski J 《METABOLISM-CLINICAL AND EXPERIMENTAL》

Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c.

Griffin MJ ，Sul HS 《IUBMB LIFE》