Bipolar II and unipolar comorbidity in 153 outpatients with social phobia.

Previous studies on social phobia (SP) have focused largely on comorbidity between SP and major depression. Less attention has been devoted to the comorbidity between SP and bipolar disorder. In this retrospective study, we investigated family history, lifetime comorbidity, and demographic and clinical characteristics among 153 outpatients who met DSM-III-R diagnostic criteria for SP. Information regarding axis I diagnoses was obtained using the Structured Clinical Interview for DSM III-R (SCID-UP-R). Social phobic symptoms and the severity of the illness were assessed by the Liebowitz Social Anxiety Scale (LSAS) and the Liebowitz Social Phobic Disorders Rating Scale, Severity (LSPDRS). Patients completed the Hopkins Symptom Checklist (HSCL 90). Fourteen patients (9.1%) satisfied DSM-III-R criteria for lifetime bipolar disorder not otherwise specified (NOS) (bipolar II), while 71 (46.4%) had unipolar major depression and 68 (44.4%) had no lifetime history of major mood disorders. Comorbid panic disorder/agoraphobia (PDA), obsessive-compulsive disorder (OCD), and alcohol abuse were reported more frequently in the bipolar group than in the other two subgroups. Unipolar patients showed higher rates of comordid PDA and OCD compared with SP patients without mood disorders. Severity and generalization of the SP symptoms, prevalent interactional anxiety, multiple comorbidity, and alcohol abuse appeared to be the most relevant consequences of SP-bipolar coexistence. In a significant minority of cases, protracted social anxiety may hypothetically have represented, along with inhibited depression, the dimensional opposite of gregarious hypomania.

Perugi G ，Frare F ，Toni C ，Mata B ，Akiskal HS ... -  《COMPREHENSIVE PSYCHIATRY》

Social anxiety symptoms across diagnoses among outpatients attending a tertiary care mood and anxiety disorders service.

Graystone HJ ，Garner MJ ，Baldwin DS 《-》

Anxiety disorders in 318 bipolar patients: prevalence and impact on illness severity and response to mood stabilizer.

Henry C ，Van den Bulke D ，Bellivier F ，Etain B ，Rouillon F ，Leboyer M ... -  《JOURNAL OF CLINICAL PSYCHIATRY》

Bipolar II and anxious reactive "comorbidity": toward better phenotypic characterization suitable for genotyping.

Akiskal HS ，Akiskal KK ，Perugi G ，Toni C ，Ruffolo G ，Tusini G ... -  《JOURNAL OF AFFECTIVE DISORDERS》

[Bipolar obsessive-compulsive disorder: confirmation of results of the "ABC-OCD" survey in 2 populations of patient members versus non-members of an association].

Hantouche EG ，Kochman F ，Demonfaucon C ，Barrot I ，Millet B ，Lancrenon S ，Akiskal HS ... -  《ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE》