Salivary anti-spectrin autoantibodies in Sjögren's syndrome.

OBJECTIVE:The purpose of this study was done to compare the anti-spectrin autoantibody levels in the parotid saliva of Sjögren's syndrome patients and in the parotid saliva of healthy control subjects. METHODS:The salivary anti-spectrin autoantibody levels of 20 Sjögren's patients and of 20 healthy controls were compared by means of the slot blot immunoassay and the alkaline phosphatase method. RESULTS:Various anti-spectrin autoantibody levels were detected in the saliva of both patients and controls. The color intensity of the blots was scored on a scale of 1 to 3. The scores were deemed to indicate the anti-spectrin autoantibody levels in saliva (1 = low, 2 = moderate, and 3 = high). The Mann-Whitney U test did not reveal a significant difference in the anti-spectrin autoantibody levels of patients and the anti-spectrin autoantibody levels of controls (P > or = .31). These results do not support a pathologic role for anti-spectrin autoantibody in Sjögren's syndrome. CONCLUSIONS:The overall result of this study substantiates that anti-spectrin autoantibodies occur naturally in saliva. Their role in immune surveillance or pathology is not clear at present.

Moody M ，Zipp M ，Al-Hashimi I 《oral surgery oral medicine oral pathology oral radiology and endodontics》

Assessment of SS-A and SS-B in parotid saliva of patients with Sjögren's syndrome.

Hammi AR ，Al-Hashimi IH ，Nunn ME ，Zipp M ... -  《-》

The effect of parotid salivary flow rate on the levels of salivary antimicrobial proteins in patients with Sjögren's syndrome.

Zipp MM ，Yasbin L ，al-Hashimi I 《QUINTESSENCE INTERNATIONAL》

Comparison of salivary calmodulin binding proteins in Sjögren's syndrome and healthy individuals.

Deming FP ，Al-Hashimi I ，Haghighat N ，Hallmon WW ，Kerns DG ，Abraham C ，Rivera-Hidalgo F ... -  《JOURNAL OF ORAL PATHOLOGY & MEDICINE》

Chemokine saliva levels in patients with primary Sjögren's syndrome, associated Sjögren's syndrome, pre-clinical Sjögren's syndrome and systemic autoimmune diseases.

Hernández-Molina G ，Michel-Peregrina M ，Hernández-Ramírez DF ，Sánchez-Guerrero J ，Llorente L ... -  《-》