Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma.

BACKGROUND:EPH family receptor tyrosine kinases and their ligand ephrins play pivotal roles in development. High-level expression of transcripts encoding EPHB6 receptors (EPHB6), its ligands ephrin-B2 and ephrin-B3 (EFNB2, EFNB3) is predictive of favorable disease outcome of neuroblastoma (NB). When combined with TrkA expression, the expression of EPHB6, EFNB2, or EFNB3 predicts more accurately the disease outcome than each of the four variables alone. PROCEDURE:Cox regression and Kaplan-Meier analyses were used to assess the prognostic significance of EPHB6, EFNB2, EFNB3, and TrkA expressions in NB without MYCN amplification. RESULTS:High-level expression of EFNB3 or TrkA predicted favorable NB outcome of NB without MYCN amplification (p < 0.03). As found in the general NB population, EPHB6, EFNB2, or EFNB3 expression in combination with TrkA expression was significantly predictive of the disease outcome of normal MYCN NB (p < 0.01). CONCLUSIONS:EPHB6, EFNB2, and EFNB3 expressions may permit further refinement of the prognostic stratification of NB into favorable and unfavorable groups.

Tang XX ，Zhao H ，Robinson ME ，Cnaan A ，London W ，Cohn SL ，Cheung NK ，Brodeur GM ，Evans AE ，Ikegaki N ... -  《medical and pediatric oncology》

Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.

Tang XX ，Zhao H ，Robinson ME ，Cohen B ，Cnaan A ，London W ，Cohn SL ，Cheung NK ，Brodeur GM ，Evans AE ，Ikegaki N ... -  《-》

High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas.

Tang XX ，Evans AE ，Zhao H ，Cnaan A ，London W ，Cohn SL ，Brodeur GM ，Ikegaki N ... -  《CLINICAL CANCER RESEARCH》

Association among EPHB2, TrkA, and MYCN expression in low-stage neuroblastomas.

Tang XX ，Evans AE ，Zhao H ，Cnaan A ，Brodeur GM ，Ikegaki N ... -  《medical and pediatric oncology》

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma.

Tang XX ，Brodeur GM ，Campling BG ，Ikegaki N ... -  《CLINICAL CANCER RESEARCH》