Natriuretic peptide system in the rat lacrimal gland.

The presence and characteristics of the natriuretic peptides and their receptors in the rat exorbital lacrimal gland were investigated. Serial dilution curves of the gland extracts were parallel to the standard curves of synthetic atrial natriuretic peptide (ANP) or C-type natriuretic peptide (CNP). Immunoreactive ANP or CNP in the gland extracts co-eluted with authentic ANP or CNP, and their contents were 4.95 +/- 0.60 and 2.87 +/- 0.53 pg mg(-1)protein (quadruplicate), respectively. By immunohistochemistry, strong immunoreactivities of ANP and CNP were co-localized in the tubules and excretory ducts of the gland, and moderate immunoreactivities were found in the myoepithelial cells and acini. Productions of guanosine 3',5'-cyclic monophosphate by particulate guanylyl cyclase in the gland membranes were stimulated by natriuretic peptides in a dose-dependent manner, and that by CNP was larger than by ANP. Messenger RNAs for ANP, CNP and their receptors were detected by reverse transcription-polymerase chain reaction. These results indicate that natriuretic peptides and their specific receptors are found in the rat lacrimal gland. Therefore, it is suggested that natriuretic peptide system may play physiological roles in the rat lacrimal gland.

Cho ES ，Kim SZ ，Kim SH ，Park BK ，Cho KW ... -  《EXPERIMENTAL EYE RESEARCH》

Coexistence of C-type natriuretic peptide and atrial natriuretic peptide systems in the bovine cornea.

Kim SZ ，Kim HS ，Lee KS ，Lee SJ ，Seul KH ，Koh GY ，Cho KW ，Kim SH ... -  《INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE》

Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum.

Kim SZ ，Kim SH ，Park JK ，Koh GY ，Cho KW ... -  《JOURNAL OF UROLOGY》

Dendroaspis natriuretic peptide and its functions in pig ovarian granulosa cells.

Piao FL ，Park SH ，Han JH ，Cao C ，Kim SZ ，Kim SH ... -  《regulatory peptides》

Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, alphaT3-1 and LbetaT2 gonadotroph cells.

Thompson IR ，Chand AN ，Jonas KC ，Burrin JM ，Steinhelper ME ，Wheeler-Jones CP ，McArdle CA ，Fowkes RC ... -  《-》