Circulating plasma endothelin-1, plasma lipids and complications in Type 1 diabetes mellitus.

UNLABELLED:The damage of endothelial integrity is an important step in the atherogenic process. To evaluate the role of circulating endothelin-1 (ET-1) in Type 1 diabetes mellitus (T1DM), plasma ET-1 levels were evaluated in T1DM patients either with (n=9) or without hyperlipidaemia (n=11), or with (n=9) and without (n=11) late diabetic complications, in non-diabetic hyperlipidaemic patients (n=17) and in healthy volunteers. Groups were matched for age, sex and body mass index. RESULTS:Serum total cholesterol and apolipoprotein B were significantly higher in the diabetic group (p<0.05). Plasma ET-1 level was similar in controls and in non-diabetic hyperlipidaemic subjects (5.77+/-1.74 ng/l vs 4.97+/-1.58 ng/l); however, diabetic hyperlipidaemic patients had a significantly higher plasma ET-1 concentration compared to control subjects (6.67+/-2.44 ng/l vs 4.97+/-1.58 ng/l, p<0.05). Diabetic patients with vascular complications had a significantly higher plasma ET-1 concentration than found in diabetic patients without complications (6.99+/-2.17 ng/l vs 4.74+/-1.27 ng/l, p<0.01) and in controls (6.99+/-2.17 ng/l vs 4.97+/ 1.58 ng/l, p<0.01). Patients with diabetic complications also had a significantly higher apolipoprotein B level compared to healthy controls (0.94+/-0.37 g/l vs 0.66+/-0.12 g/l, p<0.005). CONCLUSION:The susceptibility of T1DM patients to the development of atherosclerosis might be attributed to the relationship between elevated lipid levels and ET-1.

Sármán B ，Farkas K ，Tóth M ，Somogyi A ，Tulassay Z ... -  《diabetes nutrition & metabolism》

The relation between plasma endothelin-1 levels and metabolic control, risk factors, treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus.

Ak G ，Buyukberber S ，Sevinc A ，Turk HM ，Ates M ，Sari R ，Savli H ，Cigli A ... -  《JOURNAL OF DIABETES AND ITS COMPLICATIONS》

Lipoprotein lipids and apolipoproteins (AI, AII, B, CII, CIII) in type 1 and type 2 diabetes mellitus in young Kuwaiti women.

al-Muhtaseb N ，al-Yusef AR ，Bajaj JS 《DIABETIC MEDICINE》

Increase in thiobarbituric acid-reactive substances and vascular complications in type 2 diabetes mellitus.

Gallou G ，Ruelland A ，Campion L ，Maugendre D ，Le Moullec N ，Legras B ，Allannic H ，Cloarec L ... -  《-》

Metabolic control affects plasma lipid and apolipoprotein levels in women, but not in men, with IDDM.

Benzi L ，Marchetti P ，Giampietro O ，Miccoli R ，Pecori N ，Sanna G ，Caricato F ，Giovannitti MG ，Ciccarone AM ，Navalesi R ... -  《-》