The association between atypical adenomatous hyperplasia and primary lung cancer.

Atypical adenomatous hyperplasia (AAH) has been suggested as the adenoma in an adenoma-carcinoma sequence in the lung periphery. From 1989-1998, we undertook a systematic, prospective search for AAH in lungs resected for cancer. AAH was found in 67 of 554 patients (12. 1%) with primary lung carcinoma (9.2% in male patients and 19.0% in females). AAH was found in lungs bearing adenocarcinoma (23.2%) more frequently than with large cell undifferentiated carcinoma (12.5%) or squamous carcinoma (3.3%). A greater percentage of females with adenocarcinoma had AAH (30.2%) than did males with adenocarcinoma (18.8%). Numbers of AAH ranged from 1-42 per patient and more patients had small numbers of AAH, although 12 patients had 6 or more AAH foci. Larger numbers of AAH tended to be found in adenocarcinoma-bearing lungs. Ten of the 67 patients with AAH and primary lung carcinoma (15%) had multiple primary cancers (range 2-6), all of which were adenocarcinoma. Synchronous cancers were rare in lung tumour-bearing resections without AAH. Patients with AAH show no difference in post-operative survival to those without, for all stages of carcinoma and for Stage I disease alone. This study provides evidence for a strong association between atypical adenomatous hyperplasia and primary lung adenocarcinoma and lends weight to the AAH/adenoma-carcinoma hypothesis.

Chapman AD ，Kerr KM 《-》

The significance of associated pre-invasive lesions in patients resected for primary lung neoplasms.

Ruffini E ，Bongiovanni M ，Cavallo A ，Filosso PL ，Giobbe R ，Mancuso M ，Molinatti M ，Oliaro A ... -  《-》

Molecular alterations in atypical adenomatous hyperplasia occurring in benign and cancer-bearing lungs.

Gradowski JF ，Mantha GS ，Hunt JL ，Dacic S ... -  《diagnostic molecular pathology》

Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia.

Koga T ，Hashimoto S ，Sugio K ，Yonemitsu Y ，Nakashima Y ，Yoshino I ，Matsuo Y ，Mojtahedzadeh S ，Sugimachi K ，Sueishi K ... -  《-》

Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung.

Morandi L ，Asioli S ，Cavazza A ，Pession A ，Damiani S ... -  《LUNG CANCER》