Immunotactoid glomerulopathy--an unusual deposition disease: report of the first Malaysian case.

:A 31-year-old Malay female presented with nephrotic syndrome without renal impairment. Renal biopsy features were in keeping with immunotactoid glomerulopathy (ITG). Non-Congophilic deposits were seen causing thickening of the glomerular capillary basement membrane with segmental accentuation, and widening of the mesangium. Immunofluorescence examination showed moderate amounts of IgG and C3 in the glomerular capillary walls with some in the mesangium. Ultrastructurally, 20-nm thick fibrils with microtubular organisation were present predominantly in the subendothelial region with similar fibrils in the mesangium. Although immunotactoid glomerulopathy and fibrillary glomerulonephritis (FG) have been recognised as entities with extracellular fibrillary material in the kidney, to date much remains to be clarified regarding these 2 conditions. While the renal biopsy findings in this patient are consistent with ITG, her clinical presentation is unlike that of usual ITG in that she is of a much younger age and has no associated haemopoietic disorder. Response to initial treatment of 8 weeks of prednisolone therapy was poor.

Cheah PL ，Looi LM ，Ghazalli R ，Chua CT ... -  《Malaysian Journal of Pathology》

Fibrillary-immunotactoid glomerulopathy with renal deposits of IgAlambda: a rare cause of glomerulonephritis.

van Ginneken EE ，Assmann KJ ，Koolen MI ，Jansen JL ，Wetzels JF ... -  《CLINICAL NEPHROLOGY》

[Fibrillary immunotactoid glomerulonephritis--an unusual cause of irreversible kidney failure].

Zharfbin A ，Husek K ，Sobotová D 《-》

Monoclonal immunoglobulin G1-kappa fibrillary glomerulonephritis.

Grove P ，Neale PH ，Peck M ，Schiller B ，Haas M ... -  《MODERN PATHOLOGY》

[Diagnostic pathway of an unusual case of nephrotic syndrome: immunotactoid glomerulopathy].

Manganelli R ，Iannaccone S ，Ferbo U ，De Simone W ... -  《-》