Review: multiple endocrine neoplasia type 1, sporadic neuroendocrine tumors, and MENIN.

:Since the identification and cloning of the gene responsible for the inherited syndrome multiple endocrine neoplasia type 1 (MEN1) in 1997, important advances in the understanding of the disease, the encoded protein (MENIN) and its role in the development of sporadic neuroendocrine and other neoplasms have been made. In this review, the most important recently published data on the pathology of the MEN1 syndrome, alterations of the MEN1 gene in affected families, and sporadic neuroendocrine tumors and the possible function of MENIN will be summarized.

Komminoth P 《diagnostic molecular pathology》

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesis.

Pieterman CR ，Conemans EB ，Dreijerink KM ，de Laat JM ，Timmers HT ，Vriens MR ，Valk GD ... -  《-》

Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue.

Mailman MD ，Muscarella P ，Schirmer WJ ，Ellison EC ，O'Dorisio TM ，Prior TW ... -  《CLINICAL CHEMISTRY》

Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.

Guo SS ，Sawicki MP 《molecular endocrinology》

Pancreatic Neuroendocrine Neoplasms in Multiple Endocrine Neoplasia Type 1.

Marini F ，Giusti F ，Tonelli F ，Brandi ML ... -  《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》