自引率: 4.2%
被引量: 46775
通过率: 暂无数据
审稿周期: 1.92
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国人发稿量: 88
投稿须知/期刊简介:
Aims & scope<br>eLife publishes outstanding research in the life sciences and biomedicine, from the most fundamental and theoretical work, through to translational, applied, and clinical research. Our 32 Senior editors and 282-member Board of Reviewing Editors are among the most respected and accomplished individuals in their fields – from human genetics and neuroscience to biophysics and epidemiology. Where necessary, our Senior editors will also consult with external guest editors to evaluate new submissions.<br>接收领域<br><br>BIOCHEMISTRYBIOPHYSICS AND STRUCTURAL BIOLOGYCANCER BIOLOGYCELL BIOLOGYCOMPUTATIONAL AND SYSTEMS BIOLOGYDEVELOPMENTAL BIOLOGY AND STEM CELLSECOLOGYEPIDEMIOLOGY AND GLOBAL HEALTHGENES AND CHROMOSOMESGENOMICS AND EVOLUTIONARY BIOLOGYHUMAN BIOLOGY AND MEDICINEIMMUNOLOGYMICROBIOLOGY AND INFECTIOUS DISEASENEUROSCIENCEPLANT BIOLOGY<br>2015年数据：<br><br>DAYS TO INITIAL DECISION ----4 days<br><br>DAYS TO POST-REVIEW DECISION ---33 days<br><br>DAYS SUBMISSION TO ACCEPTANCE----116 days<br><br>At eLife, we’ve taken a fresh approach to peer review to save you time, and to provide clear direction and constructive input. Decisions are quick and efficient; revision requests are designed to be clear and manageable; and multiple rounds of revision are usually avoided. Here’s how it works:<br>Initial decisions are delivered quickly<br>Our Senior editors decide whether initial submissions are appropriate for in-depth peer review, usually in consultation with members of the Board of Reviewing Editors.<br><br>Active scientists make all decisions<br>A Senior editor assigns a member of the Board of Reviewing Editors to oversee the peer-review process. The Reviewing editor usually reviews the article him or herself, calling on one or two additional reviewers as needed.<br><br>Revision requests are consolidated<br>Reviewers get together online to discuss their recommendations, refining their feedback, and striving to provide clear and concise guidance. If the work needs essential revisions before it can be published, the Reviewing editor incorporates those requirements into a single set of instructions.<br><br>Limited rounds of revision<br>Additional rounds of revision are largely eliminated, as the Reviewing editor is able to assess most revised submissions without further outside review.<br><br>Decisions and responses are available for all to read<br>In the interests of openness and transparency we publish the most substantive parts of the decision letter after review and the associated author responses.<br><br><br><br>
期刊描述简介:
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife publishes work of the highest scientific standards and importance in all areas of the life and biomedical sciences. The research is selected and evaluated by working scientists and is made freely available to all readers without delay. eLife also invests in innovation through open-source tool development to accelerate research communication and discovery. Our work is guided by the communities we serve. eLife was founded in 2011 by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust. These organisations continue to provide financial and strategic support, and were joined by the Knut and Alice Wallenberg Foundation for 2018. Publication fees were introduced in 2017 to cover some of eLife's core publishing costs. Annual reports and financial statements are openly available.
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Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius.
In butterflies, wing colour pattern diversity and scale types are controlled by a few genes of large effect that regulate colour pattern switches between morphs and species across a large mimetic radiation. One of these genes, , has been repeatedly associated with colour pattern evolution in butterflies. Here we carried out CRISPR knockouts in multiple species and show that is a major determinant of scale cell identity. Chromatin accessibility profiling and introgression scans identified -regulatory regions associated with discrete phenotypic switches. CRISPR perturbation of these regions in black hindwing genotypes recreated a yellow bar, revealing their spatially limited activity. In the lineage, the candidate CRE from yellow-barred phenotype morphs is interrupted by a transposable element, suggesting that -regulatory structural variation underlies these mimetic adaptations. Our work shows that functionally controls scale colour fate and that its -regulatory regions control a phenotypic switch in a modular and pattern-specific fashion.
被引量：21 发表：1970
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Structural color in Junonia butterflies evolves by tuning scale lamina thickness.
In diverse organisms, nanostructures that coherently scatter light create structural color, but how such structures are built remains mysterious. We investigate the evolution and genetic regulation of butterfly scale laminae, which are simple photonic nanostructures. In a lineage of buckeye butterflies artificially selected for blue wing color, we found that thickened laminae caused a color shift from brown to blue. Deletion of the patterning gene also altered color via lamina thickening, revealing shared regulation of pigments and lamina thickness. Finally, we show how lamina thickness variation contributes to the color diversity that distinguishes sexes and species throughout the genus . Thus, quantitatively tuning one dimension of scale architecture facilitates both the microevolution and macroevolution of a broad spectrum of hues. Because the lamina is an intrinsic component of typical butterfly scales, our findings suggest that tuning lamina thickness is an available mechanism to create structural color across the Lepidoptera.
被引量：15 发表：1970
