自引率: 9.1%
被引量: 386848
通过率: 暂无数据
审稿周期: 4.48
版面费用: 13090
国人发稿量: 14361
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Scientific Reports is an online, open access journal from the publishers of Nature. We publish scientifically valid primary research from all areas of the natural and clinical sciences. Aims and scope More on the aims and scope of Scientific Reports is available in this section, as well as indexing and archiving information. Editorial Advisory Panel and Editorial Board Scientific Reports Editorial Advisory Panel and Editorial Board of researchers spans the spectrum of science, and is at the heart of what we do. Find out more, and see the Editorial Board Members in your research area in this section. Open access Scientific Reports is a fully open access journal. More on Creative Commons Attribution licenses and the benefits of publishing open access can be found in this section. Article processing charges To allow immediate global open access to all articles, Scientific Reports levies an article processing charge (APC). Current APCs and waiver information are available in this section. FAQs Answers to common questions about Scientific Reports can be found in this section. AIM Scientific Reports publishes original research in all areas of the natural and clinical sciences. We believe that if your research is scientifically valid and technically sound then it deserves to be published and made accessible to the research community. By publishing with us, your research will get the coverage and attention it deserves. Open access and continuous online publication means your work will be published swiftly, ready to be accessed by anyone, anywhere, at any time. Article Level Metrics allow you to follow the conversations your work has started. Peer review Each manuscript is handled by an Editorial Board Member, and most submissions are peer reviewed by one or more referees in addition to the Editorial Board Member. The Editorial Board — composed of practising scientists from all fields within the journals scope — manages the peer review process, and decides whether a paper should be accepted for publication. The aim of the peer review process is to establish the technical soundness of a submission, and uses a template approach. Referees and Editorial Board Members will determine whether a paper is scientifically valid, rather than making judgements on significance or whether the submission represents a conceptual advance. Fast decision and publication times Scientific Reports endeavours to make first decisions on manuscripts within 45 days. After acceptance, papers are immediately processed, and published on a daily basis. Visibility Scientific Reports articles are hosted on nature.com, which receives an average of over 8 million unique visitors each month. Weekly round-ups of all published papers, and subject-specific e-alerts, will bring further attention to your paper. Indexing Scientific Reports is indexed in ISI Web of Science, PubMed, PubMed Central, Scopus, Google Scholar and SAO/NASA ADS.
期刊描述简介:
Scientific Reports is an online, open access journal from the publishers of Nature. We publish scientifically valid primary research from all areas of the natural and clinical sciences.
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Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study.
Lung surfactants are used for reducing alveolar surface tension in preterm infants to ease breathing. Phospholipid films with surfactant proteins regulate the activity of alveolar macrophages and reduce inflammation. Aberrant skin wound healing is characterized by persistent inflammation. The aim of the study was to investigate if lung surfactant can promote wound healing. Preclinical wound models, e.g. cell scratch assays and full-thickness excisional wounds in mice, and a randomized, phase I clinical trial in healthy human volunteers using a suction blister model were used to study the effect of the commercially available bovine lung surfactant on skin wound repair. Lung surfactant increased migration of keratinocytes in a concentration-dependent manner with no effect on fibroblasts. Significantly reduced expression levels were found for pro-inflammatory and pro-fibrotic genes in murine wounds. Because of these beneficial effects in preclinical experiments, a clinical phase I study was initiated to monitor safety and tolerability of surfactant when applied topically onto human wounds and normal skin. No adverse effects were observed. Subepidermal wounds healed significantly faster with surfactant compared to control. Our study provides lung surfactant as a strong candidate for innovative treatment of chronic skin wounds and as additive for treatment of burn wounds to reduce inflammation and prevent excessive scarring.
被引量：10 发表：1970
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The effects of artocarpin on wound healing: in vitro and in vivo studies.
The skin protects the body against harmful substances and microorganisms. When the skin is damaged, wound healing must be finely regulated to restore the normal function of skin tissue. Artocarpin (ARTO), a prenylated flavonoid purified from the plant Artocarpus communis, has been reported to have anti-inflammatory and anti-cancer properties. The aim of the present study was to evaluate the wound healing potential and therapeutic mechanism of ARTO. Immunohistochemical staining of neutrophils and macrophages and mouse cytokine array analysis demonstrated that ARTO accelerates inflammatory progression and subsequently decreases persistent inflammation. ARTO increases collagen production and increases human fibroblast proliferation and migration by activating the P38 and JNK pathways. Moreover, ARTO increases the proliferation and migration of human keratinocytes through the ERK and P38 pathways and augments human endothelial cell proliferation and tube formation through the Akt and P38 pathways. Together, our data suggested that ARTO enhances skin wound healing, possibly by accelerating the inflammatory phase and by increasing myofibroblast differentiation, proliferation and migration of fibroblasts and keratinocytes, collagen synthesis and maturation, re-epithelialization, and angiogenesis. These findings indicate that ARTO has potential as a potent therapeutic agent for the treatment of skin wounds.
被引量：- 发表：1970
