自引率: 0.8%
被引量: 1442
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 12
投稿须知/期刊简介:
Nutrition & Diabetes is a peer-reviewed, open access online journal publishing clinical, metabolic, genetic and epidemiological studies that describe methodologies, mechanisms, and associations in relation to diabetes and nutrition-related diseases. The journal will also publish papers concerned with the benefits of nutrition and lifestyle interventions and therapeutic trials in diabetes or related diseases for both clinical disease management and health promotion. Nutrition & Diabetes brings to the fore outstanding research that is novel and of interest to researchers, clinicians, epidemiologists, psychologists, diabetes educators, and other health professionals working in these fields. Contributions of broad biological interest and impact are especially encouraged. Topics of particular interest within the journal's scope include those listed below: Basic science molecular biology of adipose tissue, muscle and liver molecular basis of macronutrient metabolism and inflammation genetics - tissue gene expression; genotypes, SNPs and phenotypic variability epigenetics Experimental medicine food intake regulation fat, carbohydrate and energy metabolism body compositon with focus on the assessment of individual fat depots and ectopic fat animal models of overweight and nutrition-related diseases Metabolic Syndrome aetiological factors ethnic differences relationship with disease outcomes novel therapies Dietary interventions reduction of cardiovascular disease risk factors reduction in overweight and its metabolic sequelae randomised controlled trials of dietary/lifestyle interventions in diabetes randomised, controlled trials of major dietary intervention studies e.g. fruit and vegetable/whole grains, Mediterranean diet studies on health risks use of functional food in prevention and treatment of NCDs personalized nutrition Epidemiology prospective cohort studies of links between nutrition and lifestyle on NCDs population studies of associations between nutritional factors and NCDs, with particular emphasis on regional/international variations longitudinal studies addressing critical life periods and their long-term effect on NCDs Journal metrics The 2018 journal metrics* for Nutrition & Diabetes are as follows: 2-year impact factor 3.098 5-year impact factor 3.528 Immediacy index: 0.571 Eigenfactor ® score: 0.00331 Article influence score: 1.077 Rank: 73/145 in Endocrinology & Metabolism, 38/86 in Nutrition & Dietetics
期刊描述简介:
Nutrition & Diabetes is a peer-reviewed, open access online journal publishing clinical, metabolic, genetic and epidemiological studies that describe methodologies, mechanisms, and associations in relation to diabetes and nutrition-related diseases. The journal will also publish papers concerned with the benefits of nutrition and lifestyle interventions and therapeutic trials in diabetes or related diseases for both clinical disease management and health promotion.
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Palmitic acid promotes miRNA release from adipocyte exosomes by activating NF-κB/ER stress.
被引量：- 发表：1970
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Correction: The effects of gut microbiome manipulation on glycemic indices in patients with non-alcoholic fatty liver disease: a comprehensive umbrella review.
被引量：- 发表：1970
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A potential therapeutic strategy of an innovative probiotic formulation toward topical treatment of diabetic ulcer: an in vivo study.
被引量：- 发表：1970
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Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.
Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH. We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model. GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance. This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.
被引量：- 发表：1970
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Pathogenic gene connections in type 2 diabetes and non-alcoholic fatty liver disease: a bioinformatics analysis and mouse model investigations experiments.
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) are prevalent metabolic disorders with overlapping pathophysiological mechanisms. A comprehensive understanding of the shared molecular pathways involved in these conditions can advance the development of effective therapeutic interventions. We used two datasets sourced from the Gene Expression Omnibus (GEO) database to identify common differentially expressed genes (DEGs) between T2D and NAFLD. Subsequently, we conducted Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses to identify the enriched biological processes and signaling pathways. In addition, we performed a protein-protein interaction (PPI) network analysis to identify hub genes with pivotal roles. To validate our findings, we established a type 2 diabetic mouse model with NAFLD. Our analysis identified 53 DEGs shared between T2D and NAFLD. Enrichment analysis revealed their involvement in signal transduction, transcriptional regulation, and cell proliferation as well as in the ferroptosis signaling pathways. PPI network analysis identified ten hub genes, namely CD44, CASP3, FYN, KLF4, HNRNPM, HNRNPU, FUBP1, RUNX1, NOTCH3, and ANXA2. We validated the differential expression of FYN, HNRNPU, and FUBP1 in liver tissues of a type 2 diabetic mouse model with NAFLD. Our study offers valuable insights into the shared molecular mechanisms underlying T2D and NAFLD. The identified hub genes and pathways present promising prospects as therapeutic targets to address these prevalent metabolic disorders.
被引量：- 发表：1970
