自引率: 2.8%
被引量: 26233
通过率: 暂无数据
审稿周期: 1.79
版面费用: 27930
国人发稿量: 256
投稿须知/期刊简介:
Brought to you by the editorial team of Cell Death & Differentiation, Cell Death & Disease is a peer-reviewed online journal in the field of translational cell death. It seeks to promote diverse and integrated areas of Experimental and Internal Medicine with its specialties, including Cancer, Immunity and Neuroscience. It is now accepting articles in the new section, Cancer Metabolism.Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following:Experimental medicineCancerImmunityInternal medicineNeuroscienceCancer metabolism
期刊描述简介:
Brought to you by the editorial team of Cell Death & Differentiation, Cell Death & Disease is a peer-reviewed online journal in the field of translational cell death. It seeks to promote diverse and integrated areas of experimental and internal medicine with its specialties, including cancer, immunity and neuroscience. It is now also accepting articles in a new area: cancer metabolism. Cell Death & Disease seeks to encompass the breadth of translational implications of cell death, and topics of particular concentration will include, but are not limited to, the following: Experimental medicine Cancer Immunity Internal medicine Neuroscience Cancer metabolism
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FTO/IGF2BP2-mediated N6 methyladenosine modification in invasion and metastasis of thyroid carcinoma via CDH12.
Epigenetic reprogramming plays a critical role in cancer progression of cancer, and N6-methyladenosine (m6A) is the most common RNA modification in eukaryotes. The purpose of this study was to explore the related modification mode of m6A regulator construction and evaluate the invasion and migration of thyroid cancer. Our results showed that m6A levels were significantly increased in papillary thyroid cancer (PTC) and anaplastic thyroid cancer (ATC) samples, which may have been induced by the down-regulation of demethylase fat mass and obesity-associated gene (FTO). Moreover, FTO inhibited PTC and ATC invasion and metastasis through the epithelial-to-mesenchymal transition (EMT) pathway in vivo and in vitro. Mechanistically, an m6A-mRNA epitranscriptomic microarray showed that Cadherin 12 (CDH12) is the key target gene mediated by FTO in an m6A-dependent manner. CDH12 promotes invasion and metastasis through the EMT pathway in thyroid cancer, both in vivo and in vitro. Furthermore, we found that insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is an important m6A reading protein, that regulates the stability of CDH12 mRNA and mediates EMT progression, thereby promoting the invasion and metastasis of PTC and ATC. Thus, FTO, IGF2BP2 and CDH12 may be effective therapeutic targets for PTC and ATC with significant invasion or distant metastasis. Schematic summary of FTO-IGF2BP2 axis in modulation of CDH12 mRNA m6A and upregulation of CDH12 expression in the invasion and metastasis of thyroid carcinoma.
被引量：- 发表：1970
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N-acetylaspartate promotes glycolytic-to-oxidative fiber-type switch and resistance to atrophic stimuli in myotubes.
被引量：- 发表：1970
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GPX4 restricts ferroptosis of NKp46(+)ILC3s to control intestinal inflammation.
被引量：- 发表：1970
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Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.
被引量：1 发表：1970
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Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations.
被引量：- 发表：1970
