自引率: 16.7%
被引量: 6732
通过率: 暂无数据
审稿周期: 1.31
版面费用: 暂无数据
国人发稿量: 120
期刊描述简介:
Journal of Hematology & Oncology is an open access journal that publishes top-quality research encompassing all aspects of hematology and oncology. The journal also publishes reviews and research highlights on "hot topics" from leading experts in the field. Hematology and oncology are closely intertwined and rapidly evolving fields. More physician scientists performing laboratory-based research are rapidly bringing research in hematology and oncology from bench to bedside. Journal of Hematology & Oncology aims to meet the demand for a journal dedicated to publishing discovery from both of these fields. Journal of Hematology & Oncology aims to serve as an international platform for sharing laboratory and clinical findings in an open access format among laboratory scientists, physician scientists, hematologists and oncologists. A rapid turnaround time from submission to publication means that knowledge and new successes can be shared in real time.
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Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients.
被引量：- 发表：1970
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Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia.
被引量：- 发表：1970
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Regimens combining radiation and immunotherapy for cancer: latest updates from 2024 ASCO Annual Meeting.
被引量：- 发表：1970
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Outcome after short exposure to tyrosine kinase inhibitors in pregnant female patients with chronic myeloid leukemia.
被引量：- 发表：1970
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Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies.
Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing protein structures, facilitating the repair or degradation of damaged proteins, and maintaining proteostasis and cellular functions. Extensive research has demonstrated that heat shock proteins are highly expressed in cancers and closely associated with tumorigenesis and progression. The "Hallmarks of Cancer" are the core features of cancer biology that collectively define a series of functional characteristics acquired by cells as they transition from a normal state to a state of tumor growth, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, enabled replicative immortality, the induction of angiogenesis, and the activation of invasion and metastasis. The pivotal roles of heat shock proteins in modulating the hallmarks of cancer through the activation or inhibition of various signaling pathways has been well documented. Therefore, this review provides an overview of the roles of heat shock proteins in vital biological processes from the perspective of the hallmarks of cancer and summarizes the small-molecule inhibitors that target heat shock proteins to regulate various cancer hallmarks. Moreover, we further discuss combination therapy strategies involving heat shock proteins and promising dual-target inhibitors to highlight the potential of targeting heat shock proteins for cancer treatment. In summary, this review highlights how targeting heat shock proteins could regulate the hallmarks of cancer, which will provide valuable information to better elucidate and understand the roles of heat shock proteins in oncology and the mechanisms of cancer occurrence and development and aid in the development of more efficacious and less toxic novel anticancer agents.
被引量：- 发表：1970
