自引率: 0.8%
被引量: 3574
通过率: 暂无数据
审稿周期: 暂无数据
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国人发稿量: 1
投稿须知/期刊简介:
Published by Elsevier Science. ISSN: 1521-6942.<br /><br />Best Practice & Research is a topical serial publication describing the integration of the results from the lastest original research articles into practical, evidence-based review articles that seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known. Management is described in practical terms so that it can be applied to the individual patient. The series is aimed at the physician either in practice or in training.
期刊描述简介:
Best Practice & Research is a topical serial publication describing the integration of the results from the lastest original research articles into practical, evidence-based review articles that seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known. Management is described in practical terms so that it can be applied to the individual patient. The series is aimed at the physician either in practice or in training.
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Preface to genomics of rheumatic disease.
被引量：- 发表：1970
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Challenges and complications in juvenile localized scleroderma: A practical approach.
被引量：- 发表：1970
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Preface: Pediatric rheumatology.
被引量：- 发表：1970
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The importance of functional genomics studies in precision rheumatology.
Rheumatic diseases, those that affect the musculoskeletal system, cause significant morbidity. Among risk factors of these diseases is a significant genetic component. Recent advances in high-throughput omics techniques now allow a comprehensive profiling of patients at a genetic level through genome-wide association studies. Without functional interpretation of variants identified through these studies, clinical insight remains limited. Strategies include statistical fine-mapping that refine the list of variants in loci associated with disease, whilst colocalization techniques attempt to attribute function to variants that overlap a genetically active chromatin annotation. Functional validation using genome editing techniques can be used to further refine genetic signals and identify key pathways in cell types relevant to rheumatic disease biology. Insight gained from the combination of genetic studies and functional validation can be used to improve precision medicine in rheumatic diseases by allowing risk prediction and drug repositioning.
被引量：- 发表：1970
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Personalised medicine in juvenile dermatomyositis: From novel insights in disease mechanisms to changes in clinical practice.
Juvenile dermatomyositis is characterized by childhood-onset chronic inflammation of the muscles and skin, with potential involvement of other organs. Patients are at risk for long-term morbidity due to insufficient disease control and steroid-related toxicity. Personalised treatment is challenged by a lack of validated tools that can reliably predict treatment response and monitor ongoing (subclinical) inflammation, and by a lack of evidence regarding the best choice of medication for individual patients. A better understanding of the involved disease mechanisms could reveal potential biomarkers and novel therapeutic targets. In this review, we highlight the most relevant immune and non-immune mechanisms, elucidating the effects of interferon overexpression on tissue alongside the interplay between the interferon signature, mitochondrial function, and immune cells. We review mechanism-based biomarkers that are promising for clinical implementation, and the latest advances in targeted therapy development. Finally, we discuss key steps needed for translating these discoveries into clinical practice.
被引量：- 发表：1970
