自引率: 1%
被引量: 2797
通过率: 暂无数据
审稿周期: 1.86
版面费用: 24430
国人发稿量: 9
期刊描述简介:
Cell Communication and Signaling is an open access journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions. Genetic and epigenetic changes, cell-cell, cell-environment and cell-pathogen interactions often modulate or even override programmed patterns of cell behaviour. Cell signaling is therefore not only critical for normal cell growth and development, but abnormal signals are associated with numerous human diseases. Cell Communication and Signaling strongly encourages reports of studies incorporating molecular, morphological, biochemical, structural and cell biology approaches, as well as interdisciplinary work and innovative in silico, in vitro and in vivo models that facilitate investigations of cell signaling pathways, networks and cell behaviour.
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The role of cell-cell and cell-matrix junctional complexes in sebaceous gland homeostasis and differentiation.
被引量：- 发表：1970
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Extracellular vesicles from highly invasive melanoma subpopulations increase the invasive capacity of less invasive melanoma cells through mir-1246-mediated inhibition of CCNG2.
被引量：- 发表：1970
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Adipocyte derived exosomes promote cell invasion and challenge paclitaxel efficacy in ovarian cancer.
被引量：- 发表：1970
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ONC212, alone or in synergistic conjunction with Navitoclax (ABT-263), promotes cancer cell apoptosis via unconventional mitochondrial-independent caspase-3 activation.
被引量：- 发表：1970
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A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo.
Squalene (SQ) is a well-known antioxidant and anti-inflammatory agent that provides promising anti-aging and UV-protective roles on human skin. However, its strong hydrophobic nature, accompanied by issues such as poor solubility and limited tissue permeation, has created challenges for scientists to investigate its untapped potential in more complex conditions, including cancer progression. The present study assessed the potent anti-metastatic properties of a newly synthesized amphiphilic ethylene glycol SQ derivative (SQ-diEG) in melanoma, the most fatal skin cancer. In vitro and in vivo experiments have discovered that SQ-diEG may exert its potential on melanoma malignancy through the mitochondria-mediated caspase activation apoptotic signaling pathway. The potent anti-metastatic effect of SQ-diEG was observed in vitro using highly proliferative and aggressive melanoma cells. Administration of SQ-diEG (25 mg/kg) significantly decreased the tumor burden on the lung and inhibited the metastasis-associated proteins and gene markers in B16F10 lung colonization mice model. Furthermore, global gene profiling also revealed a promising role of SQ-diEG in tumor microenvironment. We anticipated that the amphiphilic nature of the SQ compound bearing ethylene glycol oligomers could potentially augment its ability to reach the pathology site, thus enhancing its therapeutic potential in melanoma.
被引量：- 发表：1970
