自引率: 3.1%
被引量: 918
通过率: 暂无数据
审稿周期: 暂无数据
版面费用: 暂无数据
国人发稿量: 6
投稿须知/期刊简介:
The Journal of the Renin-Angiotensin-Aldosterone System (JRAAS) is a peer-reviewed open access resource for biomedical professionals, including basic scientists and clinicians, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals.<br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: Arial, Helvetica, sans-serif; font-size: 14px;"><br style="box-sizing: border-box; color: rgb(51, 51, 51); font-family: Arial, Helvetica, sans-serif; font-size: 14px;">The editors-in-chief and founders are Professor Peter Sever (Imperial College London and International Centre for Circulatory Health) and Professor Graham Macgregor (Queen Mary University of London). Both have distinguished careers in cardiovascular research, both basic and clinical including important clinical trials. Their main focus has been on the mechanisms, epidemiology and treatment of hypertension. Much of this of course has centred on the role of the renin-angiotensin system.
期刊描述简介:
The Journal of the Renin-Angiotensin-Aldosterone System (JRAAS) is a peer-reviewed open access resource for biomedical professionals, including basic scientists and clinicians, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. The editors-in-chief and founders are Professor Peter Sever (Imperial College London and International Centre for Circulatory Health) and Professor Graham Macgregor (Queen Mary University of London). Both have distinguished careers in cardiovascular research, both basic and clinical including important clinical trials. Their main focus has been on the mechanisms, epidemiology and treatment of hypertension. Much of this of course has centred on the role of the renin-angiotensin system.
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Relationship between Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of COVID-19: A Meta-Analysis.
被引量：2 发表：1970
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Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury.
Renin-angiotensin system (RAS) components exert diverse physiological functions and have been sub-grouped into deleterious angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/angiotensin type 1 receptor (AT1R) and protective ACE2/angiotensin (1-7) (Ang-(1-7))/Mas receptor (MasR) axes. We have reported that chronic activation of angiotensin type 2 receptor (AT2R) alters RAS components and provides protection against obesity-related kidney injury. We utilized AT2R knockout (AT2KO) mice in this study and evaluated the renal expression of various RAS components and examined the renal injury after placing these mice on high fat diet (HFD) for 16 weeks. The cortical ACE2 activity and MasR expression were significantly decreased in AT2KO mice compared to wild type (WT) mice. LC/MS analysis revealed an increase in renal Ang II levels and a decrease in Ang-(1-7) levels in AT2KO mice. Cortical expression of ACE and AT1R was increased but renin activity remained unchanged in AT2KO compared with WT mice. WT mice fed HFD exhibited increased systolic blood pressure, higher indices of kidney injury, mesangial matrix expansion score, and microalbuminuria, which were further increased in AT2KO mice. This study suggests that deletion of AT2R decreases the expression of the beneficial ACE2/Ang-(1-7)/MasR and increases the deleterious ACE/Ang II/AT1R axis of the renal RAS in mice. Further, AT2KO mice are more susceptible to HFD-induced renal injury.
被引量：14 发表：1970
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Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
被引量：36 发表：2006
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Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts.
被引量：13 发表：2003
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Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts.
被引量：- 发表：2002
