自引率: 1.6%
被引量: 6185
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国人发稿量: 11
投稿须知/期刊简介:
Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. Areas covered include: general biochemistry, pathobiochemistry, evolutionary biotechnology, structural biology, molecular and cellular biology, molecular medicine, cancer research, virology, immunology, plant molecular biology and biochemistry, and experimental methodologies. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published, on the average, within five months of submission. The Journal is associated with the Gesellschaft für Biochemie und Molekularbiologie (GBM).<br>''Fast Track’ publication option availableAs of September 2014, a ‘Fast Track’ manuscript processing option is available for authors of Biological Chemistry. This schedule involves accelerated handling and peer reviewing of submitted manuscripts. The shortened, yet thorough peer reviewing and rapid editorial decisions ensure swift manuscript processing in order to make your outstanding research results promptly available to the scientific community. <br style="box-sizing: inherit;">Accepted Fast Track articles are also published online in manuscript format within 2-3 working days with DOI for immediate citability. Authors who wish to apply for Fast Track processing should clearly state this in their mandatory cover letter to the Editor. Processing of submitted manuscripts in the Fast Track mode is subject to approval by the responsible Executive Editor or Editor-in-Chief. <br style="box-sizing: inherit;">High quality manuscript processing through ScholarOne<br style="box-sizing: inherit;">Manuscripts®. Please submit your manuscript online at http://mc.manuscriptcentral.com/bcRapid publication times: 48-72 hours from acceptance after peer reviewing to online publicationFree publication of color figures both in online and print editions; no page chargesOpen Access publication option availableAims and ScopeComprehensive Scope<br style="box-sizing: inherit;">Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. Areas covered include: general biochemistry, pathobiochemistry, evolutionary biotechnology, structural biology, molecular and cellular biology, molecular medicine, cancer research, virology, immunology, plant molecular biology and biochemistry, and experimental methodologies.Reviews and Minireviews<br style="box-sizing: inherit;">In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences.Rapid Publication<br style="box-sizing: inherit;">Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within 48-72 hours of acceptance.The Journal is associated with the Gesellschaft für Biochemie und Molekularbiologie (GBM).
期刊描述简介:
The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.
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The TOM complex from an evolutionary perspective and the functions of TOMM70.
In humans, up to 1,500 mitochondrial precursor proteins are synthesized at cytosolic ribosomes and must be imported into the organelle. This is not only essential for mitochondrial but also for many cytosolic functions. The majority of mitochondrial precursor proteins are imported over the translocase of the outer membrane (TOM). In recent years, high-resolution structure analyses from different organisms shed light on the composition and arrangement of the TOM complex. Although significant similarities have been found, differences were also observed, which have been favored during evolution and could reflect the manifold functions of TOM with cellular signaling and its response to altered metabolic situations. A key component within these regulatory mechanisms is TOMM70, which is involved in protein import, forms contacts to the ER and the nucleus, but is also involved in cellular defense mechanisms during infections.
被引量：- 发表：1970
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Development of an enabling platform biotechnology for the production of proteins.
Protein-based drugs are a mainstay of modern medicine. In contrast to antibodies, most of these need highly individualized production processes which often limits their development. Here, we develop an immunoglobulin domain tag (i-Tag), which can be fused to any protein of interest. This tag is made of a linear arrangement of antibody light chain constant domains. It enhances expression as well as secretion of the fusion partner and allows for simple purification of several structurally and functionally distinct fusion proteins. Furthermore, it improves the biophysical characteristics of most fusion proteins tested, is inert, and does not compromise the fusion partners' functionality. Taken together, the i-Tag should facilitate the development of biopharmaceuticals and diagnostic proteins otherwise lacking a common structural element.
被引量：- 发表：1970
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Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies.
Chimeric antigen receptor (CAR)-T cell therapy has led to remarkable clinical outcomes in the treatment of hematological malignancies. However, challenges remain, such as limited infiltration into solid tumors, inadequate persistence, systemic toxicities, and manufacturing insufficiencies. The use of alternative cell sources for CAR-based therapies, such as natural killer cells (NK), macrophages (MΦ), invariant Natural Killer T (iNKT) cells, γδT cells, neutrophils, and induced pluripotent stem cells (iPSC), has emerged as a promising avenue. By harnessing these cells' inherent cytotoxic mechanisms and incorporating CAR technology, common CAR-T cell-related limitations can be effectively mitigated. We herein present an overview of the tumoricidal mechanisms, CAR designs, and manufacturing processes of CAR-NK cells, CAR-MΦ, CAR-iNKT cells, CAR-γδT cells, CAR-neutrophils, and iPSC-derived CAR-cells, outlining the advantages, limitations, and potential solutions of these therapeutic strategies.
被引量：1 发表：1970
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Insights into caudate amphibian skin secretions with a focus on the chemistry and bioactivity of derived peptides.
Amphibians are well-known for their ability to produce and secrete a mixture of bioactive substances in specialized skin glands for the purpose of antibiotic self-protection and defense against predators. Some of these secretions contain various small molecules, such as the highly toxic batrachotoxin, tetrodotoxin, and samandarine. For some time, the presence of peptides in amphibian skin secretions has attracted researchers, consisting of a diverse collection of - to the current state of knowledge - three to 104 amino acid long sequences. From these more than 2000 peptides many are known to exert antimicrobial effects. In addition, there are some reports on amphibian skin peptides that can promote wound healing, regulate immunoreactions, and may serve as antiparasitic and antioxidative substances. So far, the focus has mainly been on skin peptides from frogs and toads (Anura), eclipsing the research on skin peptides of the ca. 700 salamanders and newts (Caudata). Just recently, several novel observations dealing with caudate peptides and their structure-function relationships were reported. This review focuses on the chemistry and bioactivity of caudate amphibian skin peptides and their potential as novel agents for clinical applications.
被引量：2 发表：1970
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Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling.
Naturally occurring gain-of-function (GOF) mutants have been identified in patients for a variety of cytokine receptors. Although this constitutive activation of cytokine receptors is strongly associated with malignant disorders, ligand-independent receptor activation is also a useful tool in synthetic biology e.g. to improve adoptive cellular therapies with genetically modified T-cells. Balanced Interleukin (IL-)7 signaling via a heterodimer of IL-7 receptor (IL-7Rα) and the common γ-chain (γc) controls T- and B-cell development and expansion, whereas uncontrolled IL-7 signaling can drive acute lymphoid leukemia (ALL) development. The ALL-driver mutation PPCL in the transmembrane domain of IL-7Rα is a mutational insertion of the four amino acids proline-proline-cysteine-leucine and leads to ligand-independent receptor dimerization and constitutive activation. We showed here in the cytokine-dependent pre-B-cell line Ba/F3 that the PPCL-insertion in a synthetic version of the IL-7Rα induced γc-independent STAT5 and ERK phosphorylation and also proliferation of the cells and that booster-stimulation by arteficial ligands additionally generated non-canonical STAT3 phosphorylation via the synthetic IL-7Rα-PPCL-receptors. Transfer of the IL-7Rα transmembrane domain with the PPCL insertion into natural and synthetic cytokine receptor chains of the IL-6, IL-12 and Interferon families also resulted in constitutive receptor signaling. In conclusion, our data suggested that the insertion of the mutated PPCL IL-7Rα transmembrane domain is an universal approach to generate ligand-independent, constitutively active cytokine receptors.
被引量：- 发表：1970
